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Autologous blood versus fibrin glue for conjunctival autograft adherence in sutureless pterygium surgery: a randomised controlled trial
  1. Abraham Kurian,
  2. Iodine Reghunadhan,
  3. K G R Nair
  1. Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India
  1. Correspondence to Dr Abraham Kurian, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala 695004, India; abrahamkurian55{at}


Aims To assess the efficacy of securing conjunctival autograft (CAG) without glue or sutures, using the patient's own blood at the surgical site, and to compare it with the current accepted standard of using fibrin glue for graft adherence, in pterygium surgery.

Methods A single-centre, prospective, randomised controlled trial was carried out in 200 eyes of patients with primary pterygia who were advised pterygium excision with CAG. Enrolled participants were assigned to Group I or II by randomisation. After excision of pterygium, they underwent CAG with autologous blood in Group I (100 eyes) and CAG with fibrin glue in Group II (100 eyes). During follow-up of 1 year, the eyes were assessed for graft adherence and recurrence.

Results Of the 200 eyes randomised, 6 eyes that did not complete intended follow-up were excluded from final analysis. Of the 194 eyes (Group I n=96, Group II n=98), on the first postoperative day, 3 eyes in Group I (3.13%) had total graft dislodgement requiring regrafting from another site or reattachment with glue. In Group II also 2 eyes (2.04%) had graft dislodgement on the first postoperative day requiring regrafting from another site. During the 1-year follow-up, 6 eyes in Group I (6.25%) and 8 eyes in Group II (8.16%) developed recurrence.

Conclusions Feasibilty of adherence of the graft without glue in pterygium surgery is promising and has results comparable with the fibrin glue technique in terms of long-term outcome and recurrence, suggesting the potential for autologous blood to replace fibrin glue in graft fixation.

Trial registration number Clinical Trial Registry, India: CTRI/2013/06/003764 and UTN: U1111-1140-6572.

  • Clinical Trial
  • Conjunctiva
  • Ocular surface
  • Treatment Surgery

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