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Ophthalmic statistics note 5: diagnostic tests—sensitivity and specificity
  1. Luke J Saunders1,
  2. Haogang Zhu1,2,
  3. Catey Bunce3,
  4. Caroline J Doré4,
  5. Nick Freemantle5,
  6. David P Crabb1 on behalf of the Ophthalmic Statistics Group,
  7. This fifth note from the Ophthalmic Statistics Group illustrates the utility of measurements of sensitivity and specificity in assessing the usefulness of a test for predicting the presence of pathology
    1. 1Department of Optometry and Visual Science, City University London, London, UK
    2. 2Institute of Ophthalmology, University College London, London, UK
    3. 3NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
    4. 4UCL Comprehensive Clinical Trials Unit, University College London, London, UK
    5. 5Department of Primary Care and Population Health, University College London, London, UK
    1. Correspondence to Dr David P Crabb, Department of Optometry and Visual Science, School of Health Sciences, City University London, Northampton Square, London EC1V 0HB, UK; d.crabb{at}


    This is the fifth statistics note produced by the Ophthalmic Statistics Group (OSG) which is designed to be a simple guide to ophthalmic researchers on a statistical issue with an applied ophthalmic example. The OSG is a collaborative group of statisticians who have come together with a desire to raise the statistical standards of ophthalmic researcher by increasing statistical awareness of common issues.

    • Diagnostic tests/Investigation
    • Epidemiology

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