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Research Article
Prenatal exclusion of Norrie's disease.
  1. R M Redmond,
  2. C A Graham,
  3. E D Kelly,
  4. M Coleman and
  5. N C Nevin
  1. Department of Ophthalmology, Queen's University, Belfast.

    Abstract

    We report on the use of DNA marker probes and linkage analysis to exclude Norrie's disease in the male fetus of a high risk carrier. There are no clinical markers in females carrying the Norrie's disease gene; thus DNA linkage analysis is an essential technique in the management of families 'at-risk' for this severe ophthalmic disease. The principles of DNA linkage are discussed.

    https://doi.org/10.1136/bjo.76.8.491

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