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Original Article
Intrafamilial variation of the phenotype in Bardet–Biedl syndrome
  1. Ruth Riisea,
  2. Sten Andréassonb,
  3. Margareta K Borgströmc,
  4. Alan F Wrightd,
  5. Niels Tommerupe,
  6. Thomas Rosenbergf,
  7. Kristina Tornqvistb
  1. aDepartment of Ophthalmology, Central Hospital of Hedmark, Hamar, Norway, bDepartment of Ophthalmology, University Hospital of Lund, Sweden, cDepartment of Pedodontics, School of Dentistry, Malmö, University of Lund, Sweden, dMRC, Human Genetics Unit, Western General Hospital, Edinburgh, UK, eDepartment of Medical Genetics, The John F Kennedy Institute, Glostrup, Denmark, fNational Eye Clinic for the Visually Impaired, Copenhagen, Denmark
  1. Dr Ruth Riise, Department of Ophthalmology, Central Hospital of Hedmark, N-2300 Hamar, Norway.

Abstract

AIMS To describe the variation of the phenotype within families with several individuals with Bardet–Biedl syndrome.

METHODS The phenotypes of affected siblings in 11 Scandinavian families were compared with two or more members who had at least three of the features: retinal dystrophy, polydactyly, obesity, hypogenitalism, and mental retardation. Individuals without retinal dystrophy were excluded.

RESULTS Intrafamilial variation of expressivity of the features obesity, polydactyly, abnormal radiograms of the extremities, hypogenitalism, short stature, paraplegia, and dental abnormalities was found. The retinal dystrophy varied with respect to both the onset of symptoms and the course of the disease. The morphology of the fundus, however, was consistent within the families. The disorder showed statistically significant genetic linkage to the BBS4 locus on chromosome 15 in the affected siblings in two of the families, but the clinical features in these patients did not differ from the other cases of Bardet–Biedl syndrome.

CONCLUSION Comparison of siblings with the Bardet–Biedl syndrome showed variation of the typical features. In addition, the course of retinal dystrophy varied. No distinctive clinical features were found to separate the BBS4 phenotype from the remaining patients.

  • Bardet–Biedl syndrome
  • phenotype
  • intrafamilial variation

https://doi.org/10.1136/bjo.81.5.378

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