You are here

Article Text

Article menu
Download PDFPDF
Singapore SERI-ARVO Meeting
Risk factors for conjunctival squamous cell neoplasia: a matched case-control study
  1. W Tulvatana1,
  2. P Bhattarakosol2,
  3. L Sansopha3,
  4. W Sipiyarak1,
  5. E Kowitdamrong2,
  6. T Paisuntornsug3,
  7. S Karnsawai3
  1. 1Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  2. 2Department of Microbiology
  3. 3Department of Pathology
  1. Correspondence to: Wasee Tulvatana, MD, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Bangkok 10330, Thailand; wasee{at}softhome.net

Abstract

Aims: To identify roles of human papillomavirus (HPV) infection and solar elastosis as the risk factors for conjunctival squamous cell neoplasia (CSCN).

Methods: 30 consecutive pathological specimens, ranging from conjunctival intraepithelial neoplasia, carcinoma in situ, to invasive squamous cell carcinoma were retrieved from tissue archives. 30 controls were disease free conjunctiva from age and sex matched patients undergoing extracapsular cataract extraction. Two masked pathologists studied haematoxylin and eosin stains on paraffin embedded conjunctival tissues. Elastic stain for solar elastosis was blindly interpreted in comparison with negative and positive controls. HPV infection was studied by polymerase chain reaction and dot hybridisation.

Results: The mean age of CSCN patients was 54.9 years. The male to female ratio was 1:1. Solar elastosis was seen in 53.3% of CSCN and in 3.3% of controls with an odds ratio of 16.0 (95% CI, 2.49 to 670.96; p value = 0.0003). HPV DNA were not detected in any of the specimens.

Conclusion: Solar elastosis is much more frequently found in CSCN cases than in their matched controls and is a risk factor for CSCN. These data are insufficient to conclude that HPV infection is a risk factor for CSCN.

https://doi.org/10.1136/bjo.87.4.396

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes