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P-glycoprotein expression in retinoblastoma
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We have read with interest the paper by Krishnakumar et al.1 We have studied 18 children with retinoblastoma using immunohistochemical detection of P-glycoprotein by the mouse monoclonal antibody HYB-241 in frozen section tumour samples. Like Krishnakumar et al, we found limited expression of P-glycoprotein in retinoblastoma cells since only four of the 18 samples were positive. However, six of 18 samples had P-glycoprotein positivity in tumour associated endothelial cells. Contrary to Krishnakumar et al, we had …
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Disclosure: There is no financial interest of the authors with any of the drugs and devices mentioned.