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Face-down posturing after macular hole surgery: A meta-analysis
  1. Andrew Tatham*,
  2. Somnath Banerjee
  1. University Hospitals of Leicester, United Kingdom
  1. To whom correspondence should be addressed. E-mail: andrewtatham{at}


Aims: To assess the effect that the duration of face-down posturing has on the outcome of macular hole surgery.

Methods: A literature search was conducted to identify studies related to posturing duration following macular hole surgery. Where appropriate, studies were compared in a meta-analysis. The Mantel-Haenszel fixed effect method was used to calculate the summary statistics. The main outcome measures were macular hole closure rate and visual acuity improvement.

Results: 17 studies investigating the effect of face-down posturing time on the outcome of macular hole surgery were identified. 9 studies included a comparison group and were deemed suitable for inclusion in the meta-analysis. Studies were divided into two groups depending on the duration of face-down posturing investigated. The meta-analysis revealed a relative risk of anatomical failure of 1.34 (95% CI 0.66 – 2.72) with face-down posturing for 24 hours or less compared to face-down posturing for 5 to 10 days, however this was not statistically significant (p=0.42). Study design was too dissimilar to allow meaningful comparison of visual acuity outcomes.

Conclusions: Currently there is insufficient evidence to allow firm conclusions as to whether face down posturing following macular hole surgery influences hole closure rates. Meta-analyses are limited by the quality of included studies; a well conducted randomised control trial is needed.

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