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In vitro emulsification assessment of new silicone oils
  1. Albert Caramoy*,
  2. Sabine Schröder,
  3. Sascha Fauser,
  4. Bernd Kirchhof
  1. 1 University of Cologne, Center of Ophthalmology, Germany
  1. Correspondence to: Albert Caramoy, Department of vitreoretinal surgery, University of Cologne, Center of Ophthalmology, Kerpener Strasse 62, Cologne, 50924, Germany; acaramoy{at}


Purpose: To investigate whether the emulsification of conventional silicone oils can be reduced by adding small amounts of silicone molecules of very long chain length.

Methods: Siluron 1000, Siluron 2000, Siluron 5000, Acri.Sil-Ol® 5000, Oxane® 5700, Densiron 68 LV, Densiron 68, and Densiron 68 HV (0.5 ml) were each tested along with either plasma or serum (0.5 ml) in a glass cuvette. Emulsification was induced by sonication and documented by photography. The total area of emulsified oil was assessed using the ImageJ software.

Results: The addition of small amounts of very long-chain silicone molecules significantly reduced the emulsification rate for 1000 cSt silicone oil (Siluron 2000) and for 1000 cSt silicone oil with admixture of F6H8 (Densiron 68 HV).

Conclusion: New low-viscosity silicone oils show reduced emulsification similar to 5000 cSt oils. In future, it may be possible to avoid using 5000 cSt oils. The findings may foster silicone oil surgery in general and particularly the application of small-incision techniques.

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