You are here

  • Home
  • Online First
  • Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese

Article Text

Article menu

other Versions

Download PDFPDF
Clinical science
Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese
  1. X Yang,
  2. J Hu,
  3. J Zhang,
  4. H Guan
  1. Department of Ophthalmology, the Affiliated Hospital of Nantong University, Nantong, China
  1. Correspondence to Huaijin Guan, Department of Ophthalmology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, China; gtnantongeye{at}gmail.com

Abstract

Background/Aims Single nucleotide polymorphisms (SNPs) in Complement Factor H (CFH), HTRA1 and CX3CR1 are associated with age-related macular degeneration (AMD) in Caucasian population. We aimed to determine whether, and of what magnitude, these AMD susceptibility SNPs are associated with exudative AMD in Han Chinese.

Methods Exudative AMD cases and age-matched controls were recruited from Nantong University Hospital (109 cases, 150 controls). Six SNPs in CFH, HTRA1 and CX3CR1 were genotyped. The allele/genotype frequencies were compared between the case and the control. Interactions of SNP–SNP or SNP–smoking status were assessed.

Results The CFH rs800292 showed significant associations with a reduced risk for exudative AMD. CX3CR1 V249I and T280M and the HTRA1 promoter SNP were significantly associated with the risk of exudative AMD. The two SNPs in CX3CR1 were in complete linkage disequilibrium. None of the AMD-susceptibility SNPs had interactions with each other or with smoking status to confer an altered AMD risk.

Conclusions We have replicated the associations of the CFH and HTRA1 SNPs and report for the first time the association of CX3CR1 with exudative AMD in Han Chinese. There was no interaction among the SNPs from different genes, indicating that they might alter the AMD risk independently.

  • Age-related macular degeneration (AMD)
  • complement factor H
  • HTRA1
  • CX3CR1
  • macula
  • epidemiology
  • immunology
  • genetics
  • degeneration

https://doi.org/10.1136/bjo.2009.165811

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Xiaozhao Yang works as a resident in the Eye Research Institute, Xi'an No. 1 Hospital, China.

    • Funding Nantong University.

    • Competing interests None.

    • Ethics approval This study was conducted with the approval of the Nantong University Ethics Committee.

    • Provenance and peer review Not commissioned; externally peer reviewed.