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Salzmann nodular degeneration was first described by Maximilian Salzmann.1 It is more often associated with chronic corneal diseases2 and is not considered to be hereditary.
We describe this condition in four women in four successive generations, all direct descendants. Corneal histological report was available from one patient. We shall refer to these cases as case nos. 1, 2, 3 and 4 as they occur in chronological order, although case no. 2 presented to us first (index case).
Case no. 1 (great grandmother)
She was born in 1905. The records date back to 1971 when she was registered visually impaired due to bilateral corneal degenerative changes.
She underwent penetrating keratoplasties of the right and left eye in 1972 and 1973, respectively. Ten years postoperatively, recurrence of degenerative changes was noted on the grafts. No further intervention was carried out. She died of natural …
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