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Photoreceptor impairment on optical coherence tomographic images in patients with retinitis pigmentosa
  1. Akira Hagiwara1,
  2. Yoshinori Mitamura2,
  3. Ken Kumagai1,
  4. Takayuki Baba1,
  5. Shuichi Yamamoto1
  1. 1Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan
  2. 2Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
  1. Correspondence to Professor Yoshinori Mitamura, Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan; ymitaymitaymita{at}yahoo.co.jp

https://doi.org/10.1136/bjophthalmol-2012-302510

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    Morphological assessments of the photoreceptors can be useful in estimating the disease progression in retinitis pigmentosa (RP).1–3 Using spectral-domain optical coherence tomography, the external limiting membrane (ELM) and cone outer segment tips (COST) can be clearly detected in addition to photoreceptor inner/outer segment junction (IS/OS). To date, the IS/OS as well as the ELM and COST have been analysed after macular surgery.4 ,5 In RP patients, however, changes of the COST line and correlations among the IS/OS, ELM and COST lines remain unclear.

    We have already reported that the IS/OS length was significantly correlated with visual acuity or retinal sensitivity and that the progressive IS/OS shortening is associated with worsening of visual function during RP progression.1 ,2 The purposes of this study were to examine the changes of the COST line in RP patients and to investigate the correlations among the IS/OS, ELM and COST lines.

    After obtaining approval from the Institutional Review Board and informed consent, this study was done on 263 eyes of 133 consecutive patients with RP. RP patients were …

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    Footnotes

    • Contributors AH attended the cases, analysed data and drafted the manuscript. YM analysed data, interpreted data and drafted the manuscript. KK and TB attended the cases and analysed data. SY supervised physicians, interpreted data and revised the manuscript. YM had full access to all of the data in the study and takes responsibility for the integrity of the data and accuracy of the data analysis.

    • Competing interests None.

    • Patient consent Informed consent was obtained from each patient after a through explanation of the procedures to be used.

    • Ethics approval Ethics approval was provided by the Institutional Review Board of Chiba University Hospital.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement Data are available from the corresponding author upon request.