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Optical coherence tomography in paediatric glaucoma: time domain versus spectral domain
  1. Fatema F Ghasia,
  2. Sharon F Freedman,
  3. Anand Rajani,
  4. Sandra Holgado,
  5. Sanjay Asrani,
  6. Mays El-dairi
  1. Department of Ophthalmology, Duke Eye Center, Durham, North Carolina, USA
  1. Correspondence to Dr Mays El-Dairi, Department of Ophthalmology, Duke Eye Center, Durham, NC 27710, USA; mays.el-dairi{at}


Background/aims Spectral-domain (SD)- Optical Coherence Tomography (OCT) can track eye movements, has faster acquisition time and higher resolution than time-domain(TD)-OCT. The aim of the study was to assess the utility of SD-OCT in paediatric glaucoma and determine its agreement with TD-OCT.

Methods Children who had SD-OCT(Spectralis, Heidelberg-Engineering,Germany) were retrospectively and prospectively identified from Duke paediatric glaucoma clinic. The peripapillary retinal nerve fibre layer (RNFL) and macular thickness and volume (MV) were compared amongst four groups: normal eyes, eyes with physiologic cupping (C:D >0.5 and <0.8, IOP <21), mild glaucomatous eyes (C:D <0.5, intra-ocular pressure (IOP) >21) and severe glaucoma (C:D>0.5, IOP>21). SD-OCT values were compared to TD-OCT(OCT-3, Carl-Zeiss-Meditec, Dublin, CA) values in a subset of subjects who had same day scans using both instruments. Children with neurologic disorders, refractive error >±5D, pseudophakia and prematurity were excluded.

Results Included were 83 eyes of 83 children, mean age 11.9±4.2 years. SD-OCT measurements of average RNFL thickness and MV differed among normals(n=24), physiologically cupped (n=31), mild (n=15) versus severe glaucoma (n=13): (RNFL:104±9, 99±6, 98±9 vs62±18 µm, respectively, p<0.05; MV: 8.7±0.3, 8.6±0.3, 8.8±0.4 vs8.0±0.6 mm³, respectively, p<0.05). Same-day SD-OCT and TD-OCT measures in 53 eyes correlated linearly (RNFL r2=0.88; MVr2=0.58). SD-OCT measured lower RNFL and higher macular thickness than TD-OCT. Among eyes with severe glaucoma, 4 of 13 (30%) had unreliable TD-OCT but reliable SD-OCT.

Conclusions SD-OCT was easier to obtain than TD-OCT in children. SD-OCT and TD-OCT measurements correlated, but values were not interchangeable.

  • Glaucoma
  • Imaging

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