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Increased risk of coronary heart disease in male patients with central serous chorioretinopathy: results of a population-based cohort study
  1. San-Ni Chen1,2,
  2. Yi-Chiao Chen3,
  3. Iebin Lian3,4
  1. 1Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan
  2. 2School of Medicine, Chung Shan Medical University, Taichung, Taiwan
  3. 3Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua, Taiwan
  4. 4Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
  1. Correspondence to Dr I B Lian, Graduate Institute of Statistics and Information Science, National Changhua University of Education, #1 Jinde Rd, Changhua 50002, Taiwan; maiblian{at}


Aims To investigate whether patients with central serous chorioretinopathy (CSCR) have increased risk of coronary heart disease (CHD).

Methods Population-based retrospective cohort and case control study. Longitudinal data from the Taiwan National Health Insurance Research Database (2000–2009) were analysed. The study cohort comprised 835 patients with a diagnosis of CSCR and 4175 age and gender matched patients without CSCR. Kaplan–Meier plots and log-rank tests were used to compare differences in the hazard rates of CHD between the CSCR and non-CSCR cohorts. Stratified Cox proportional hazard models were applied to examine the association between CSCR and CHD, adjusting for potential confounding factors.

Results The 5-year CHD cumulative incidence for patients with CSCR was nearly twofold that of the non-CSCR cohort (6.12% vs 3.29%, p=0.004) from the log-rank test. The adjusted CHD HR of CSCR versus non-CSCR was 1.61 (95% CI 1.12 to 2.30, p=0.009) from the Cox model. Specifically, the HR for male patients was 1.72 (95% CI 1.14 to 2.59, p=0.010) and for female patients it was 1.34 (95% CI 0.64 to 2.84, p=0.438).

Conclusions Male patients with CSCR had a significantly higher CHD rate than those without CSCR, indicating that CSCR may be a potential risk factor for the development of CHD for men.

  • Epidemiology
  • Public Health
  • Choroid

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