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I thank Dr Tan and associates for their comments1 regarding my article entitled ‘Results of 2 years of treatment with as-needed ranibizumab reinjection for polypoidal choroidal vasculopathy (PCV)’,2 and welcome the opportunity to discuss treatment of PCV. In their comments, Dr Tan and associates pointed out the apparently higher regression rate of polypoidal lesions after photodynamic therapy (PDT) compared with ranibizumab (Lucentis, Genentech, South San Francisco, California, USA) monotherapy and emphasised the important implication of regression of polypoidal lesions in the outcomes of treatment for PCV.
The EVEREST study,3 a randomised controlled trial of PDT alone or in combination with ranibizumab compared with ranibizumab monotherapy for PCV, concluded that PDT is more effective than ranibizumab for achieving regression of …
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