Footnotes

• Collaborators The following are members of THE FRIENDS GROUP (FRench Institutional ENDophthalmitis Study group): Thierry Zhou (France, Grenoble), Florent Aptel (France, Grenoble), Alain M Bron (France, Dijon), Pierre-Loïc Cornut (France, Lyon), Karine Palombi (France, Grenoble), Gilles Thuret (France, Saint-Etienne), Frédéric Rouberol (France, Lyon), Catherine Creuzot-Garcher (France, Dijon), Christophe Chiquet (France, Grenoble). The entire list of participants of the FRIENDS group is provided below.

• THE FRIENDS GROUP (FRench Institutional ENDophthalmitis Study group)

• Participants:

• Study coordinator: Christophe Chiquet MD, PhD

• Statistics, methodology, microbiological techniques: Gilles Thuret, MD, PhD; François Vandenesch, MD, PhD; Max Maurin, MD, PhD

• Database management: Pierre-Loïc Cornut, MD, PhD

• Ophthalmology:

• ▸ University Hospital of Dijon: Marie Passemard, MD; Catherine Creuzot-Garcher, MD, PhD; Alain M Bron, MD

• ▸ University Hospital of Grenoble: Christophe Chiquet, MD, PhD; Florent Aptel, MD, PhD; Aurélie Combey de Lambert, MD; Karine Palombi, MD; Thierry Zhou, MD; Eva Brillat-Zaratzian, MD; Jean-Paul Romanet, MD, PhD

• ▸ University Hospital of Lyon (E. Herriot Hospital): Pierre-Loïc Cornut; Frédéric Rouberol, MD; Carole Burillon, MD, PhD; Philippe Denis, MD, PhD

• ▸ University Hospital of Saint-Etienne: Nelly Campolmi, MD, PhD; Gilles Thuret, MD, PhD; Philippe Gain, MD, PhD

• Microbiology:

• ▸ University Hospital of Dijon: André Péchinot, PhD; Catherine Neuwirth, MD, PhD

• ▸ University Hospital of Grenoble: Sandrine Boisset, PhD; Max Maurin, MD, PhD

• ▸ University Hospital of Lyon: Jérôme Etienne, MD; Yvonne Benito Engineer; Anne Tristan, MD; François Vandenesch, MD, PhD

• ▸ University Hospital of Saint-Etienne: Anne Carricajo, PhD; Gérard Aubert, PhD

• Mycology:

• ▸ University Hospital of Dijon: Frédéric Dalle, MD, PhD; Alain Bonin, MD, PhD

• ▸ University Hospital of Grenoble: Bernadette Lebeau, MD; Hervé Pelloux, MD, PhD

• ▸ University Hospital of Lyon: Frédérique de Montbrison, MD; Stéphane Picot, MD, PhD

• ▸ University Hospital of Saint-Etienne: Hélène Raberin, MD; Roger Tran Manh Sung, MD, PhD

• Contributors TZ designed data collection tools, monitored data collection for the whole trial, wrote the statistical analysis plan, cleaned and analysed the data, and drafted and revised the paper. He is guarantor. FA drafted and revised the paper. AMB monitored data collection from Dijon hospital and revised the draft paper. P-LC contributed to the monitoring of database and revised the paper. KP monitored data collection from Grenoble hospital and revised the paper. GT monitored data collection from Saint-Etienne hospital and revised the draft paper. FR monitored data collection from Lyon hospital and revised the paper. CC-G initiated the collaborative project, monitored data collection from Dijon hospital, and drafted and revised the paper. CC initiated the collaborative project, designed data collection tools, implemented the trial for the all cities, monitored data collection for the whole trial, analysed the data, and drafted and revised the paper.

• Funding Health Ministry (PHRC, French public programme of clinical research), AFAU (French association of unilateral amblyopia), ARFO (Association for Research in Ophthalmology, Grenoble) and THEA laboratory.

• Competing interests None declared.

• Patient consent Obtained.

• Ethics approval Local institutional review board IRB# 5921.

• Provenance and peer review Not commissioned; externally peer reviewed.