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Update on corneal neurotisation
  1. Raman Malhotra1,
  2. Mohamed Shafik Elalfy1,
  3. Ruben Kannan2,
  4. Charles Nduka2,
  5. Samer Hamada1
  1. 1 Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, East Grinstead, UK
  2. 2 Department of Plastic Surgery, Queen Victoria Hospital, East Grinstead, UK
  1. Correspondence to Raman Malhotra, Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, East Grinstead RH19 3DZ, UK; Raman.malhotra1{at}


Corneal neurotisation describes surgical restoration of nerve growth into the cornea to restore corneal sensation and trophic function. It represents an exciting and effective emerging treatment for neurotrophic keratopathy. Techniques described to date involve either direct nerve transfer or an interpositional nerve graft coapted to a healthy donor nerve. We review the experience to date with particular emphasis on a detailed review of techniques, outcomes and current thoughts.

  • cornea
  • neurotization
  • nerve graft
  • nerve transfer
  • neurotrophic keratopathy

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  • RM and MSE are joint first authors.

  • Contributors RM planned for the review. RM and MSE designed the work and provided first draft of figure. RM, MSE, RK, CN and SH edited the manuscript and reviewed the literature. All authors provided final proof-reads.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement This is a review article.