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Conjunctival myxoid stromal tumour: a distinctive clinicopathological and immunohistochemical study
  1. Xiao-Yi Qin,
  2. Zhe-Hao Jin,
  3. You-Pei Wang,
  4. Zong-Duan Zhang
  1. Eye Hospital of Wenzhou Medical University, Wenzhou, China
  1. Correspondence to Dr Zong-Duan Zhang, Eye Hospital of Wenzhou Medical University, Wenzhou 325027, China; zzduan{at}yeah.net

Abstract

Background/aims To describe the clinicopathological and immunohistochemical characteristics of 10 patients representing a new entity of benign conjunctival myxoid stromal tumours.

Methods Retrospective review of clinical findings, histopathological and immunohistochemical studies identified 10 cases of low-grade conjunctival myxoid stromal tumours. Specimens were routinely processed and stained with H&E. Immunohistochemical stains for CD34, CD68, vimentin, S100, smooth muscle actin (SMA), myosin, desmin, actin, Bcl-2 and Ki-67 were performed. Specific stains for Alcian-blue periodic acid-Schiff (AB-PAS) and aldehyde fuchsin stains were also performed.

Results Ten patients with an average age of 45.6±11.1 years had a tender white or faint yellow to red mass on the bulbar conjunctiva. All the lesions were completely removed, and none of the patients relapsed. Histologically, all neoplasms consisted of spindle-shaped cells that showed signs of pseudonuclear inclusions, multinuclear cells and had no atypia. The stroma consisted of a large amount of mucus and was infiltrated with delicate to ropey collagens, a few mast cells and new vessels. Immunohistochemical stains were positive for CD34, vimentin and Bcl-2; partial positive for CD68; very low for Ki-67; and negative for S100, SMA, myosin, desmin and actin. AB-PAS suggested that the stroma was mucinous.

Conclusions These rare benign mesenchymal conjunctival tumours are mostly unilateral and occur in the bulbar conjunctiva. Complete resection is the radical treatment. These lesions are characterised by multiple spindle cells, a large amount of mucus, and sharing similar basic histopathological features with conjunctival myxoma and conjunctival stromal tumour. We suggest naming these lesions ‘conjunctival myxoid stromal tumours’.

  • myxoid stromal tumor
  • conjunctiva
  • clinicopathological features

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Footnotes

  • Contributors All authors contributed to drafting this work or revising it critically for important intellectual content and provided approval for it to be published. All authors are in agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors acquired the data. ZDZ, ZHJ and XYQ analysed the data. ZDZ and XYQ contributed to the conception and design of the work.

  • Funding This work received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Disclaimer The author(s) have no proprietary interest in any materials discussed in this article.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethics Committee of Eye Hospital of Wenzhou Medical University, Wenzhou, China.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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