Background/aims To determine whether the development of non-arteritic anterior ischaemic optic neuropathy (NAION) is increased among patients newly diagnosed with obstructive sleep apnoea (OSA) in a large general population.
Methods A 12-year nationwide, population-based, retrospective cohort study including 1 025 340 beneficiaries in the 2002–2013 Korean National Health Insurance Service database was performed. We identified 919 patients newly diagnosed with OSA aged ≥40 years and matched 9190 non-OSA controls using estimated propensity scores in reference to age, sex, demographics, comorbidities and co-medications. We applied Kaplan-Meier curves and Cox proportional hazard models to determine the risk of developing NAION in the OSA group compared with the non-OSA group.
Results The 10-year incidence probability of NAION was higher in the OSA group (0.92%; 95% CI 0.88 to 0.97) than the non-OSA group (0.42%; 95% CI 0.41 to 0.44, p=0.002, log-rank test). The OSA group was at increased risk of developing NAION compared with the non-OSA group (HR 3.80; 95% CI 1.46 to 9.90) after adjusting for demographics, comorbidities and co-medications.
Conclusions Our results suggest that patients with newly diagnosed OSA have an increased risk of NAION, although the absolute risk of NAION is low.
- obstructive sleep apnea
- ischemic optic neuropathy
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HKY and SJP are joint first authors.
Contributors HKY, SJP, JWK and JMH contributed to conception and design. SJB contributed to data collection. Literature screening, selection, preparation and review of the manuscript were performed by HKY, SJP, KHP, JWK and JMH. All authors read and approved the final manuscript.
Funding This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2017R1A2B4011450).
Competing interests None declared.
Patient consent Not required.
Ethics approval Institutional review board (IRB) of the Seoul National University Bundang Hospital.
Provenance and peer review Not commissioned; externally peer reviewed.
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