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Collateral vessels on optical coherence tomography angiography in eyes with branch retinal vein occlusion
  1. Norihiro Suzuki,
  2. Yoshio Hirano,
  3. Taneto Tomiyasu,
  4. Ryo Kurobe,
  5. Yusuke Yasuda,
  6. Yuya Esaki,
  7. Tsutomu Yasukawa,
  8. Munenori Yoshida,
  9. Yuichiro Ogura
  1. Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  1. Correspondence to Dr Yoshio Hirano, Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 4678601, Japan; yoshio.hirano{at}gmail.com

Abstract

Aims To detect collateral vessels using optical coherence tomography angiography (OCTA) in eyes with branch retinal vein occlusion (BRVO) and to investigate the associations with visual outcomes and macular oedema.

Methods Eyes with macular oedema secondary to BRVO that underwent OCTA at baseline and were followed up for more than 6 months were enrolled. The presence of collaterals, whether the collaterals were leaky or not, and the associations with visual outcomes and macular oedema were investigated.

Results Twenty-eight eyes of 28 patients (8 men and 20 women; mean age, 68 years) were enrolled. Collaterals were detected in 23 eyes (82%) and already existed at the initial visit. Collaterals were more frequently detected in eyes with major BRVO or ischaemic type. One-third of the collaterals were leaky and all of the leaky collaterals had microaneurysms (MAs) inside. Macular oedema in eyes with collaterals was more quickly and frequently resolved than that in eyes without collaterals, but there were no significant differences. Collateral vessel formation did not seem to impact on visual outcomes, but the mean baseline central retinal thickness (CRT) was significantly higher in eyes with collaterals, and the mean CRT reduction at 6 months after treatments was significantly greater than in eyes without collaterals.

Conclusions These results suggest that collateral vessels are formed at the acute phase in eyes with BRVO. In addition, the presence of collaterals might be associated with absorption of macular oedema, but MAs formed in collaterals sometimes can cause macular oedema.

  • optical coherence tomography angiography
  • branch retinal vein occlusion
  • collateral vessels
  • macular edema
  • multimodal imaging

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Footnotes

  • Contributors YH designed the study protocol. NS, YH, TT, RK, YY and YE collected the data. NS and YH performed the analysis and interpretation. NS and YH wrote the manuscript. TY, MY and YO supervised the study.

  • Funding YH was supported by a Grant-in-Aid for Scientific Research (C) (18K09416) from the Japan Society for the Promotion of Science (Tokyo, Japan), Aichi Health Promotion Foundation (Nagoya, Japan) and the Eye Research Foundation for the Aged (Odawara, Japan). The Japan Society for the Promotion of Science also supported TT (Grant-in-Aid for Young Scientists (B) 17K16977), TY (Grant-in-Aid for Scientific Research (C) 16K11293) and YO (Grant-in-Aid for Scientific Research (B) 15H04997).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study protocol was approved by the Institutional Review Board of Nagoya City University Graduate School of Medical Sciences (No 60180113). The described research methods and analysis adhered to the tenets of the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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