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Rate of three-dimensional neuroretinal rim thinning in glaucomatous eyes with optic disc haemorrhage
  1. Yong Woo Kim1,
  2. Won June Lee2,
  3. Bo Ram Seol3,
  4. Young Kook Kim1,
  5. Jin Wook Jeoung1,
  6. Ki Ho Park1
  1. 1Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
  2. 2Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea
  3. 3Ophthalmology, VHS Medical Center, Seoul, South Korea
  1. Correspondence to Ki Ho Park, Ophthalmology, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea; kihopark{at}snu.ac.kr

Abstract

Background To investigate the thinning rate of three-dimensional neuroretinal rim thickness (3D-NRT) in glaucoma eyes with optic disc haemorrhage (DH) and its relationship to retinal nerve fibre layer thickness (RNFLT) progression.

Methods Ninety-five (95) eyes of 95 glaucoma patients with initial DH in the inferotemporal (n=69) and superotemporal (n=26) regions and 48 eyes of 48 glaucoma patients without DH were retrospectively reviewed. The rates of change for 3D-NRT and RNFLT were compared by linear mixed-effect model. For the direct comparison between 3D-NRT and RNFLT, dynamic-range-based normalised coefficient was used. The effect of DH frequency on the rates of thinning of 3D-NRT and RNFLT was evaluated.

Results During a mean 7-year follow-up, the rates of thinning of 3D-NRT (–5.69±4.88 µm/year) and RNFLT (–2.03±2.03 µm/year) at 7 o’clock were faster than those at other locations (all p<0.05) in DH eyes. The dynamic-range-based normalised rate of thinning was significantly faster for RNFLT (–2.06%±1.62%/year) than for 3D-NRT (–1.15%±1.10%/year, p<0.001) in DH eyes, but not in non-DH eyes (p=0.43). DH frequency in the inferotemporal region was associated with the thinning rate of 3D-NRT as well as RNFLT.

Conclusion DH eyes are associated with the progression of both 3D-NRT and RNFLT, especially in the inferotemporal region. DH eyes show a relatively faster thinning rate of average RNFLT than 3D-NRT. The frequency of DH can affect the progression of 3D-NRT as well as RNFLT.

  • glaucoma
  • imaging
  • optic nerve
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Footnotes

  • Contributors YWK, KHP: Study design, data preparation, data review, data analysis, data interpretation, manuscript preparation, manuscript revision. WJL, BRS, YKK, JWJ: data preparation, data review, data interpretation, manuscript preparation.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by the SNUH Institutional Review Board and followed the tenets of the Declaration of Helsinki (1964).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon request.

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