Article Text

Download PDFPDF
Longitudinal changes in the ganglion cell-inner plexiform layer thickness in high myopia: a prospective observational study
  1. Min Woo Lee1,2,
  2. Ki Yup Nam3,
  3. Hye Jin Park1,
  4. Hyung-Bin Lim1,
  5. Jung-Yeul Kim1
  1. 1 Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Korea
  2. 2 Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea
  3. 3 Department of Ophthalmology, Gyeongsang National University Changwon Hospital, Changwon, Korea
  1. Correspondence to Professor Jung-Yeul Kim, Department of Ophthalmology, Chungnam National University Hospital, Daejeon 301-721, Korea; kimjy{at}cnu.ac.kr

Abstract

Aim To determine longitudinal changes of the ganglion cell-inner plexiform layer (GC-IPL) thickness in patients with high myopia.

Methods The subjects were divided into two groups: a high myopia group (axial length ≥26.0 mm) and a normal control group. Both groups were divided into subgroups based on age (decade): 20s, 30s, 40s and 50s. Twenty eyes were included in each subgroup. After the initial visit, GC-IPL thicknesses were measured three more times with at least a 1-year interval between examinations using spectral domain optical coherence tomography. The average GC-IPL thickness was fitted with linear mixed models.

Results The average GC-IPL thickness at the first visit was 78.50 ± 8.79 µm and 84.29 ± 6.12 µm in the high myopia and control groups, respectively. In both groups, the average GC-IPL thickness showed a significant change over time. The rate of GC-IPL reduction in individuals aged in their 50s, 40s, 30s and 20s with high myopia were −0.81 µm/year,–0.51 µm/year, −0.28 µm/year and −0.12 µm/year, respectively, and in controls in their 50s, 40s, 30s and 20s, they were −0.31 µm/year,–0.25 µm/year, −0.12 µm/year and −0.02 µm/year, respectively. Additionally, individuals aged in their 50s showed a statistically significant interaction between group and duration (p<0.001).

Conclusions Highly myopic eyes had thinner GC-IPL and a significantly greater reduction in GC-IPL over 3 years when compared with normal eyes. Additionally, the reduction rate of the GC-IPL thickness was greater in older patients in both groups, which was more prominent in the high myopia group.

  • high myopia
  • ganglion cell-inner plexiform layer
  • spectral domain optical coherence tomography
View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors Design and conduct of the study (MWL, J-YK); Collection of data (MWL, HJP, J-YK); Analysis and interpretation of data (MWL, KYN, H-BL, J-YK); Writing the article (MWL, J-YK); Critical revision of the article (MWL, J-YK); Final approval of the article (MWL, KYN, H-BL, HJP, J-YK).

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Institutional Review Board of Chungnam National University Hospital, Daejeon, Republic of Korea.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No data are available.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.