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Central serous chorioretinopathy: risk factors for serous retinal detachment in fellow eyes
  1. Ari Shinojima1,2,
  2. Chadi Mehanna3,4,
  3. Carlo Alessandro Lavia1,
  4. Alain Gaudric1,
  5. Ramin Tadayoni1,4,
  6. Elodie Bousquet4,5
  1. 1Ophthalmology, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, University Sorbonne Paris Cité, Paris, France
  2. 2Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  3. 3Biostatistics, Hôpital Necker-Enfants Malades, AP-HP, Paris, France
  4. 4Ophthalmology, Hôpital Hôtel-Dieu Cochin, Ophtalmopôle, Assistance Publique-Hôpitaux de Paris, AP-HP, Université Paris 5, Sorbonne Paris Cité, Paris, France
  5. 5INSERM U1138, Team 17, Université Paris Descartes Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Paris, France
  1. Correspondence to Dr Ari Shinojima, Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan; ariearly7{at}gmail.com

Abstract

Background/Aims To assess risk factors for serous retinal detachment (SRD) in the fellow eye of patients with central serous chorioretinopathy (CSC) based on clinical data and multimodal imaging findings, including baseline late-phase indocyanine green angiography (ICGA).

Methods Consecutive patients with unilateral CSC were retrospectively assessed. Inclusion criteria were the availability of late-phase ICGA and a spectral-domain optical coherence tomography (OCT) macular cube for both eyes at baseline and over 3 months. Subsequent OCT of fellow eyes was reviewed to detect the development of SRD during the follow-up. Baseline medical data and multimodal imaging findings were analysed using Kaplan-Meier survival curves (log-rank test).

Results Sixty-eight patients with unilateral CSC were included. An SRD was detected in 19% of fellow eyes during a mean follow-up of 25.8±18.7 months. Hyperfluorescent plaques on midphase ICGA, hypofluorescent foci on late-phase ICGA, retinal pigment epithelium changes on fundus autofluorescence and fluorescein angiography abnormalities were associated with the occurrence of SRD (log-rank test; p<0.001, p=0.02, p=0.002 and p=0.001, respectively).

Conclusion These results suggest that the fellow eyes with specific findings on multimodal imaging in patients with unilateral CSC should be carefully followed up for possible incidence of CSC.

  • Retina
  • Macula
  • Diagnostic tests/Investigation
  • Imaging
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Footnotes

  • Contributors AS and EB designed and conducted the study and collected the data; CM and EB analysed the data. All authors interpreted the data and gave their final approval of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The study protocol and procedures used were approved by the ethics committee of the French Society of Ophthalmology (institutional review board (IRB) 00008855 Société Française d’Ophtalmologie IRB#1). This research was conducted in compliance with the tenets of the Declaration of Helsinki. Written informed consent was obtained from all patients before performing any examination.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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