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Selective laser trabeculoplasty versus topical medication as initial glaucoma treatment: the glaucoma initial treatment study randomised clinical trial
  1. Ghee Soon Ang1,
  2. Eva K Fenwick2,3,4,
  3. Marios Constantinou3,
  4. Alfred Tau Liang Gan2,
  5. Ryan Eyn Kidd Man2,
  6. Robert J Casson5,
  7. Eric A Finkelstein4,
  8. Ivan Goldberg6,
  9. Paul R Healey6,7,
  10. Konrad Pesudovs8,9,
  11. Sutha Sanmugasundram3,
  12. Jing Xie3,
  13. Rachel McIntosh3,
  14. Jonathan Jackson10,11,
  15. Anthony P Wells12,
  16. Andrew White6,7,13,
  17. Keith Martin1,3,14,15,
  18. Mark J Walland1,
  19. Jonathan G Crowston2,3,4,15,
  20. Ecosse Luc Lamoureux2,3,4
  1. 1Glaucoma Investigation and Research Unit, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
  2. 2Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Singapore
  3. 3Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
  4. 4Duke-NUS Medical School, Singapore, Singapore, Singapore
  5. 5Ophthalmology and Visual Sciences, South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, South Australia, Australia
  6. 6Discipline of Ophthalmology, The University of Sydney, Sydney, New South Wales, Australia
  7. 7Westmead Institute for Medical Research, Sydney, New South Wales, Australia
  8. 8School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  9. 9Vision and Eye Research Institute, Anglia Ruskin University, Cambridge, United Kingdom
  10. 10National Vision Research Institute, Australian College of Optometry, Melbourne, Victoria, Australia
  11. 11Royal Victoria Hospital (BHSCT), Belfast, Northern Ireland
  12. 12Capital Eye Specialists, Wellington, New Zealand
  13. 13Cambridge NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK
  14. 14Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  15. 15Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia
  1. Correspondence to Dr Ecosse Luc Lamoureux, Ophthalmology, University of Melbourne, Melbourne, VIC 3010, Australia; ecosse{at}unimelb.edu.au

Footnotes

  • JGC and ELL are joint senior authors.

  • GSA and EKF contributed equally.

  • Contributors GSA and EKF contributed equally as first authors and wrote the manuscript and interpreted the data; MC ran the trial and drafted sections of the paper; ATLG and JX conducted the data analysis, assisted with interpretation of results and drafted sections of the paper; REKM assisted with interpretation of results and drafted sections of the manuscript; RJC, IG, PRH, KP, JJ, APW, AW, KM and MJW contributed to the study protocol; ELL and JGC contributed to the conception of the work and interpretation of the data; all authors revised the manuscript critically for important intellectual content.

  • Funding This Randomised Controlled Trial was funded by a Project Grant from the Australian National Health and Medical Research Council (NHMRC #1009844-EL as PI). CERA receives operational infrastructure support from the Victorian Government. Last and corresponding author ELL was funded by a NHMRC Research Fellowship (#1045280) and co-last author JGC was funded by an NHMRC Practitioner Fellowship (#529915) and by the Dorothy Adele Edols Charitable Trust. Co-main author EKF was funded by an NHMRC Early Career Fellowship (#1072987).

  • Competing interests IG has the following conflicts of interest to declare: Advisory Board member for Allergan, Novartis, Mundipharma; Speaker Bureau for Allergan, Novartis; Travel support from Pfizer. KM has the following conflicts of interest to declare: Consultant to Allergan, Novartis, Quethera, Sensimed.

  • Patient consent for publication Written informed consent was collected from each participant prior to commencement in the study. Recruitment started in 2012 and ceased in 2017.

  • Ethics approval The study was conducted according to the tenets of the Declaration of Helsinki and ethical approval was obtained the Human Research Ethics Committee (HREC) of the Royal Victorian Eye and Ear Hospital (Reference number 11/1024 hour), Westmead Hospital (Reference number 2011/10/4.1 (3391) AU RED HREC/11/WMEAD/229), the Royal Australian and New Zealand College of Ophthalmologists (Reference number 34.11), the Health and Disability Ethics Committees of New Zealand (Reference number 12/STH/13), the Southern Adelaide Clinical Human Research Ethics Committee (Reference number 81.13) and National Research Ethics Services Cambridge East (Reference number 13/EE/0204) the Australian College of Optometry Human Research Ethics Committee (Ref H13 002).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon request.

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Footnotes

  • JGC and ELL are joint senior authors.

  • GSA and EKF contributed equally.

  • Contributors GSA and EKF contributed equally as first authors and wrote the manuscript and interpreted the data; MC ran the trial and drafted sections of the paper; ATLG and JX conducted the data analysis, assisted with interpretation of results and drafted sections of the paper; REKM assisted with interpretation of results and drafted sections of the manuscript; RJC, IG, PRH, KP, JJ, APW, AW, KM and MJW contributed to the study protocol; ELL and JGC contributed to the conception of the work and interpretation of the data; all authors revised the manuscript critically for important intellectual content.

  • Funding This Randomised Controlled Trial was funded by a Project Grant from the Australian National Health and Medical Research Council (NHMRC #1009844-EL as PI). CERA receives operational infrastructure support from the Victorian Government. Last and corresponding author ELL was funded by a NHMRC Research Fellowship (#1045280) and co-last author JGC was funded by an NHMRC Practitioner Fellowship (#529915) and by the Dorothy Adele Edols Charitable Trust. Co-main author EKF was funded by an NHMRC Early Career Fellowship (#1072987).

  • Competing interests IG has the following conflicts of interest to declare: Advisory Board member for Allergan, Novartis, Mundipharma; Speaker Bureau for Allergan, Novartis; Travel support from Pfizer. KM has the following conflicts of interest to declare: Consultant to Allergan, Novartis, Quethera, Sensimed.

  • Patient consent for publication Written informed consent was collected from each participant prior to commencement in the study. Recruitment started in 2012 and ceased in 2017.

  • Ethics approval The study was conducted according to the tenets of the Declaration of Helsinki and ethical approval was obtained the Human Research Ethics Committee (HREC) of the Royal Victorian Eye and Ear Hospital (Reference number 11/1024 hour), Westmead Hospital (Reference number 2011/10/4.1 (3391) AU RED HREC/11/WMEAD/229), the Royal Australian and New Zealand College of Ophthalmologists (Reference number 34.11), the Health and Disability Ethics Committees of New Zealand (Reference number 12/STH/13), the Southern Adelaide Clinical Human Research Ethics Committee (Reference number 81.13) and National Research Ethics Services Cambridge East (Reference number 13/EE/0204) the Australian College of Optometry Human Research Ethics Committee (Ref H13 002).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon request.

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