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Lamina cribrosa pore movement during acute intraocular pressure rise
  1. Ya Xing Wang1,
  2. Qi Zhang1,
  3. Hongli Yang2,
  4. Jian Dong Chen1,
  5. Ningli Wang1,
  6. Jost B Jonas1,3
  1. 1Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
  2. 2Devers Eye Institute, Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, United States
  3. 3Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Mannheim, Germany
  1. Correspondence to Dr Ya Xing Wang, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing 100005, China; yaxingw{at}gmail.com

Abstract

Purpose To assess changes in the position of lamina cribrosa pores (LCPs) induced by acute intraocular pressure (IOP) elevation.

Methods A prospective observational study. Acute angle-closure suspects who underwent the 2-hour dark room prone provocative test (DRPPT) were included. At baseline and within 5 min after the DRPPT end, tonometry, fundus photography and optical coherence tomography were performed. Optic disc photos taken before and after the DRPPT were aligned and moving distance of each visible LCP was measured (LCPMD).

Results 38 eyes from 27 participants (age: 52.5±10.8 years) were included. The IOP rose from 16.7±3.2 mm Hg at baseline to 23.9±4.3 mm Hg at the DRPPT end. The mean lateral LCPMD was 28.1±14.6 µm (range: 5.0–77.2 µm), which increased with higher IOP rise (p=0.01) and deeper optic cup (p=0.02) in multivariate analysis. The intralamina range and SD of the LCPMD increased with younger age (p=0.01 and p=0.02, respectively) and with wider optic cup (p=0.01 and p=0.02, respectively). The LCP movements were headed to the superior direction in 12 (33%) eyes, inferior direction in 10 (28%) eyes, temporal direction in 9 (25%) eyes, and nasal direction in 5 (14%) eyes.

Conclusions IOP rise is associated with LCP movements in the frontal plane, which are more pronounced with higher IOP rise and deeper optic cup. The intralamina variability in the IOP rise-associated LCPMD increased with younger age and wider optic cup. IOP variation-associated lateral LCP movements may be of interest to elucidate glaucomatous optic nerve damage.

  • Glaucoma
  • Imaging
  • Intraocular pressure
  • Optic Nerve

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Correction notice The paper has been slightly amended since it was published Online First. There were a couple of typographic errors which have since been corrected.

  • Contributors YXW: design, concept, analysis, writing. QZ: application, data collection, analysis. HY: analysis. JDC: patient examination, data collection. NW: patient examination. JBJ: design, writing.

  • Funding National Natural Science Foundation of China #81570835.

  • Competing interests None declared.

  • Ethics approval The Ethical Review Committee of Beijing Tongren Hospital approved the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on request.

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