Article Text

Download PDFPDF
Identifying central serous chorioretinopathy biomarkers in coexisting diabetic retinopathy: a multimodal imaging study
  1. Deven Sushil Dhurandhar1,
  2. Sumit Randhir Singh2,
  3. Niroj Kumar Sahoo2,
  4. Abhilash Goud2,
  5. Marco Lupidi3,
  6. Jay Chhablani2
  1. 1 Retina and Vitreous, L V Prasad Eye Institute, Hyderabad, India
  2. 2 Vitreo-retina, L V Prasad Eye Institute, Hyderabad, India
  3. 3 Department of Ophthalmology, University of Perugia, Perugia, Italy
  1. Correspondence to Dr Jay Chhablani, Vitreo-retina, L V Prasad Eye Institute, Hyderabad 500 034, India; jay.chhablani{at}gmail.com

Abstract

Background To describe clinical and imaging characteristics of patients presenting with diabetic retinopathy (DR) with coexisting acute or chronic central serous chorioretinopathy (CSCR).

Methods This was a cross-sectional study which included 54 eyes of 27 patients with coexisting DR and CSCR. Demographic details, prior history of laser, best-corrected visual acuity (BCVA), central macular thickness (CMT), height of neurosensory detachment (NSD), subfoveal choroidal thickness (SFCT), subfoveal large choroidal vessel layer thickness (SF-LCVT), fluorescein angiography and indocyanine green angiography features were recorded. Subanalysis was done for patients with unilateral CSCR. Data was evaluated using Student t-test for quantitative data and χ2 test for qualitative data. CSCR between different grades of DR was analysed using analysis of variance.

Results Prevalence of coexistent CSCR in eyes with DR was 0.4%. Mean age was 53.96±8.79 years, with 25 males. Mean CMT was 349.2±258 μm. Mean SFCT and SF- LCVT of 38 eyes were 376.40±86 μm and 178.80±62.8 μm, respectively. Fifteen eyes had centre involving diabetic macular oedema. Subanalysis of patients with unilateral CSCR showed that the loss of inner segment-outer segment (IS-OS) integrity (p=0.001), photoreceptor footplates at the NSD roof (p=0.001) on optical coherence tomography and dilated choroidal vessels (p=0.05) on indocyanine green angiography were found more often in the CSCR eyes compared with their fellow eyes. Features of CSCR among the different grades of DR were not significantly different between the groups.

Conclusion Our study describes features of a unique subset of patients presenting with coexistent DR and CSCR. Such coexistent nature needs special attention by the clinicians as this may change the treatment approach and alter outcomes.

  • diabetic macular edema (DME)
  • central serous chorioretinopathy (CSCR)
  • optical coherence tomography (OCT)
View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors ML and JC designed the study; DSD, SRS and JC conducted the study; DSD, SRS and AG collected the data; DSD managed the data; DSD, SRS, NKS and JC analysed the data; SRS and JC interpreted the data. DSD, AG and SRS prepared the manuscript; ML and JC reviewed the manuscript; ML and JC approved the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Hyderabad Eye Research Foundation, LV Prasad Eye Institute.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No data are available.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.