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Effect of low-dose atropine on myopia progression, pupil diameter and accommodative amplitude: low-dose atropine and myopia progression
  1. Aicun Fu1,
  2. Fiona Stapleton2,
  3. Li Wei3,
  4. Weiqun Wang3,
  5. Bingxin Zhao3,
  6. Kathleen Watt4,
  7. Na Ji5,
  8. Yong Lyu6
  1. 1Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
  2. 2Optometry, UNSW, Sydney, New South Wales, Australia
  3. 3The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
  4. 4Optometry, UNSW, Sydney, New South Wales, Australia
  5. 5The Affiliated Eye Hospital of Suzhou Vocational Health College, Suzhou, China
  6. 6The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
  1. Correspondence to Professor Yong Lyu, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China; lyong{at}zzu.edu.cn

Abstract

Purpose To evaluate the effects of 0.01% and 0.02% atropine eye drops on myopia progression, pupil diameter and accommodative amplitude in myopic children.

Methods A cohort study assessed 400 myopic children divided into three groups: 138 and 142 children were randomised to use either 0.02% or 0.01% atropine eye drops, respectively. They wore single-vision (SV) spectacles, with one drop of atropine eye drop applied to both eyes once nightly. Control children (n=120) only wore SV spectacles. Repeated measurements of spherical equivalent refractive errors (SERs), axial length (AL), pupil diameter and accommodative amplitude were performed at baseline, and 4, 8 and 12 months after treatment.

Results After 12 months, the SER change was −0.38±0.35D, −0.47±0.45D, −0.70±0.60D and AL change was 0.30±0.21 mm, 0.37±0.22 mm, 0.46±0.35 mm in the 0.02%, 0.01% atropine and control groups, respectively. There were significant differences in the change in AL and SER between three groups (all p<0.001). Between baseline and the 12-month visit, the overall change in accommodative amplitude was 1.50±0.25D, 1.61±0.31D and change in pupil diameter was 0.78±0.42 mm, 0.69±0.39 mm, with 0.02% and 0.01% atropine, respectively. Accommodative amplitude significantly decreased and pupil diameter significantly increased in two atropine groups (all p<0.001). Moreover, there was no statistical difference in the change difference in accommodative amplitude and pupil diameter between two atropine groups (p=0.24, p=0.38), whereas the accommodative amplitude (p=0.45) and pupil diameter (p=0.39) in the control group remained stable.

Conclusions 0.02% atropine eye drops had a better effect on myopia progression than 0.01% atropine, but 0.02% and 0.01% atropine showed similar effects on pupil diameter and accommodative amplitude after 12 months of treatment.

Trial registration number ChiCTR-IPD-16008844.

  • drugs
  • clinical trial
  • child health (paediatrics)
  • optics and refraction
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Footnotes

  • Contributors Study concept and design: AF, FS, YL. Acquisition, analysis or interpretation of data: AF, LW, WW, BZ, NJ, YL. Revised paper for important intellectual content and final approval of the version submitted for publication: AF, FS, KW, YL. Study supervision: YL.

  • Funding The study was funded by Medical Science and Technology Research Project of Henan Health Commission (201602073); Key R&D and Promotion Project of Henan Science and Technology Department (201801591); Key Scientific Research Project of Universities of Henan Education Department (19A320066).

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Ethics approval This study was approved by the human ethics committee of the First Affiliated Hospital of Zhengzhou University (registration no. 2016-35).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No data are available.

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