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Retinal blood flow reduction in normal-tension glaucoma with single-hemifield damage by Doppler optical coherence tomography
  1. Takafumi Yoshioka1,
  2. Youngseok Song1,
  3. Motofumi Kawai1,
  4. Tomofumi Tani1,
  5. Kengo Takahashi1,
  6. Satoshi Ishiko1,
  7. Fabio Lavinsky2,
  8. Gadi Wollstein3,
  9. Hiroshi Ishikawa3,
  10. Joel S Schuman3,
  11. Akitoshi Yoshida1
  1. 1Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
  2. 2Lavinsky Eye Institute, Porto alegre, Brazil
  3. 3NYU Langone Eye Center, New York University School of Medicine, New York, New York, USA
  1. Correspondence to Dr Youngseok Song, New York University, New York, NY 10012-1126, USA; prorenata2002{at}gmail.com

Abstract

Aims To evaluate the associations between retinal blood flow (RBF) and optical coherence tomography (OCT) structural measurements in normal-tension glaucoma (NTG) eyes with single-hemifield visual field (VF) damage by the Doppler OCT.

Methods The Doppler OCT was used to measure temporal artery (TA) RBF and temporal vein (TV) RBF. Retinal nerve fibre layer thickness (RNFLT) was measured by spectral-domain OCT.

Results Forty-three consecutive eyes of 43 patients with NTG with VF defect confined to a single hemifield and 24 eyes of 24 age-matched healthy subjects were studied. TA and TV RBF and RNFLT were reduced in the damaged hemisphere compared with the normal hemisphere (mean (SD), 3.61 (1.68) vs 5.86 (2.59) µL/min, p<0.001; 5.61 (2.51) vs 6.94 (2.83) µL/min, p=0.010; 69.0 (19.7) vs 99.7 (22.8) µm, p<0.001). Those values in the normal hemisphere of NTG eyes also decreased compared with the healthy hemisphere of the healthy eyes (8.40 (3.36) µL/min, p<0.001; 9.28 (4.47) µL/min, p<0.002; 122.8 (20.2) µm, p<0.001). Multivariate model showed that normal and damaged hemispheres and RNFLT were associated with RBF reduction. In addition, the RBF in the normal hemisphere was lower than that in the healthy hemisphere even after adjusting for RNFLT.

Conclusion In NTG eyes with single-hemifield damage, the RBF was significantly reduced in the damaged hemisphere compared with the normal one. The RBF decreased in the normal and damaged hemispheres of NTG eyes compared with the healthy hemisphere independent from RNFLT.

  • glaucoma
  • field of vision
  • imaging
  • retina
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Footnotes

  • TY and YS are joint first authors.

  • TY and YS contributed equally.

  • Contributors TY and YS for data acquisition, design, data analysis, statistical analysis and drafting the manuscript. MK and TT for data acquisition. KT and SI for critical revision of the manuscript. FL, GW, HI, and JSS for drafting the manuscript and critical revision of the manuscript. AY for data acquisition and critical revision of the manuscript.

  • Funding The work was supported by JSPS KAKENHI Grant Number 16k20296.

  • Competing interests Akitoshi Yoshida has a patent for the Doppler OCT system.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by the Institutional Review Boards of Asahikawa Medical University (approval number: 17114), which is in agreement with the tenets of the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available in a public, open access repository. Data are available upon reasonable request. Data may be obtained from a third party and are not publicly available. All data relevant to the study are included in the article or uploaded as supplementary information. All data in the study are available to share. Please contact Youngseok Song should you have any request/inquiry for data sharing.

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