Article Text
Abstract
Background To identify and analyse the character and relationship between flat irregular pigment epithelial detachment feature (FIPED), choroidal thickness and choroidal neovascularisation (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with central serous chorioretinopathy (CSCR) in Chinese patients.
Method In the present study, 152 eyes of 144 Chinese patients, who were previously diagnosed with CSCR, were retrospectively studied. Patients’ baseline characteristics, the course of CSCR, best-corrected visual acuity, the pattern of CNV on OCTA, FIPED and choroidal thickness detected by enhanced depth imaging-OCT (EDI-OCT) were analysed.
Results It was disclosed that 7.23% of CSCR patients had CNV. Age and the course of CSCR were found to be correlated with the occurrence of CNV. Among the eyes with CNV network (11 eyes), 100% of them had FIPED, whereas, among the eyes without CNV (141 eyes), 18.04% had FIPED. The maximum width and en-face area of PED were greater in the CNV group compared with that in the non-CNV group (p<0.001). It also was revealed that female gender and a poor vision were risk factors for CNV in eyes with CSCR. The choroidal thickness detected by EDI-OCT was also statistically significant between eyes with CNV and eyes without CNV. The patients who have CNV complicated with FIPED are susceptible to have low vision.
Conclusion The present research demonstrated that the majority of CNV cases were linked to FIPED, and the thinner thickness of choroid. The greater width and en-face area of PED may point towards the presence of an underlying CNV network.
- retina
- imaging
- diagnostic tests/investigation
- public health
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Footnotes
TL and WL contributed equally.
Contributors Study conception and design: TL and WL. Data collection and Data analysis: TL, WL and SZ. First article draft and article review: TL and WL.
Funding This work was supported by grants from the Natural Science Foundation of China (No.81500710) and the projects of medical and health technology development programme in Shandong province (No. 2016WS0526); Shandong Key Research and Development Project (2016 GSF 201088, 2019GSF108189); Shandong Province TCM Science and Technology Development Plan Project (2015-150); Shandong Medical and Health Science and Technology Development Plan (2015BJYB28).
Competing interests None declared.
Patient consent for publication Obtained.
Ethics approval The Human Research and Ethics Committee of Shandong Eye Hospital, Shandong Eye Institute, Shandong First Medical University and Shandong Academy of Medical School (2019-G-012) granted ethical approval for the study.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available on reasonable request. Patients were previously diagnosed at Shandong Eye Hospital and Shandong Eye Institute, Shandong First Medical University and Shandong Academy of Medical School, Data about patients are available on reasonable request.
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