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Clinical science
Impact of myopia on the association of long-term intraocular pressure fluctuation with the rate of progression in normal-tension glaucoma
  1. Jinho Lee1,2,
  2. Eun Jung Ahn2,3,
  3. Yong Woo Kim2,4,
  4. Ahnul Ha2,5,
  5. Young Kook Kim2,4,
  6. Jin Wook Jeoung2,4,
  7. Ki Ho Park2,4
  1. 1 Department of Ophthalmology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea (the Republic of)
  2. 2 Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
  3. 3 Daehakro Seoul Eye Clinic, Seoul, Korea (the Republic of)
  4. 4 Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  5. 5 Department of Ophthalmology, Jeju National University Hospital, Jeju, Korea (the Republic of)
  1. Correspondence to Ki Ho Park, Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea; kihopark{at}snu.ac.kr

Abstract

Background/Aims To investigate whether the association of long-term intraocular pressure (IOP) fluctuation with the rate of progression of normal-tension glaucoma (NTG) differs between myopia and non-myopia.

Methods The medical records of 65 myopic NTG (axial length (AL) > 24.0 mm) and 64 non-myopic NTG eyes (AL < 24.0 mm), who had been treated with topical medications for more than 5 years, were reviewed. Multiple linear regression models were fitted to analyse the relationships of the slope of mean deviation (MD) or visual field index (VFI) with the clinical factors, including the interactions with myopia.

Results The average follow-up period was 8.3 years. Twenty-two (22) non-myopic eyes (34.4%) and 27 myopic eyes (41.5%) showed NTG progression (p=0.511). The interaction of myopia with IOP fluctuation was a significant factor regarding both MD and VFI slope (p=0.002, 0.024, respectively); stratified analyses suggested that the risk effect of IOP fluctuation was significant only in myopic NTG in terms of both MD (β= −1.27, p=0.003) and VFI slope (β=−2.32, p=0.011).

Conclusion Long-term IOP fluctuation was significantly related to faster visual field progression in myopic NTG eyes, compared with non-myopic NTG eyes.

  • Glaucoma
  • Genetics
  • Optic nerve
  • Ciliary body
  • Aqueous humour
  • Angle
  • Imaging
  • Field of vision
  • Intraocular pressure

https://doi.org/10.1136/bjophthalmol-2019-315441

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    Footnotes

    • JL and EJA contributed equally.

    • Contributors JL, EJA and KHP contributed to the design and conduct of the study. YKK, KHP, JWJ, YWK and AH contributed to the collection of data. JL, AH, YKK, KHP, JWJ and AH contributed to the analysis and interpretation of data. JL, EJA and KHP contributed to the writing the article. JL, YWK, AH, YKK, JWJ and KHP contributed to critical revision of the article. All authors agreed to the final approval of the work and account for its integrity.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Data sharing statement Data are available upon reasonable request.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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