Purpose To assess the association of anterior segment optical coherence tomography (AS-OCT) parameters and 5-year incident narrow angle in China.
Methods This was a prospective cohort study of people aged 50 and older residing in Liwan District, Guangzhou, China. Random clustering sampling was used to identify adults aged 50 years and older in Liwan District, Guangzhou. In 2008 and 2013, this study was repeated and added AS-OCT imaging under dark and light conditions. Customised software (ZAAP) was used to analyse horizontal AS-OCT scans. Angle opening distance (AOD), trabecular iris space area (TISA), anterior chamber volume (ACV) and maximal iris thickness (ITM) were measured. Multiple logistic regression analysis models were used to investigate the associations of the final angle status with baseline AS-OCT parameters. ORs and 95% CIs were calculated.
Results Of the 220 subjects with eligible AS-OCT images and gonioscopic results in 2008, the response rate was 77.3%. A total of 27 (15.9%) subjects developed narrow angles and 143 (84.1%) had open angles on gonioscopy in 2013. Subjects developed narrow angles had greater spherical equivalent and shallower anterior chamber depth, smaller angle parameters, thicker IT750 and ITM, smaller anterior chamber parameters, greater lens vault, and smaller dynamic parameters (ΔITM, ΔACA, ΔACV) at baseline. After adjusting confounders, the predictors of incident narrow angles included smaller AOD750, TISA750, ΔACA and greater ITM, ΔIarea.
Conclusions Incident narrow angles were associated with smaller anterior ocular dimensions, thicker iris and smaller light-to-dark changes at baseline. These findings can help in early diagnosis in this population.
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YJ and WW are co-first authors.
Contributors Research design was conducted by MH. Data acquisition and research execution were carried out by LW. Data analysis and interpretation were performed by YJ and WW. The manuscript was finished by YJ and WW, proofread and revised by MH.
Funding This research was supported in part by the grant from National Natural Science Foundation of China (81125007) and the Fundamental Research Funds of the State Key Laboratory in Ophthalmology. This research was funded by Sun Yat-sen University Graduate Student Innovation and Development Foundation (19ykyjs44) and Science and Technology Planning Project of Guangzhou City in China (201904010192 ). Professor Mingguang receives support from the University of Melbourne at Research Accelerator Program and the CERA Foundation. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian State Government. No additional external funding was received. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests None declared.
Ethics approval The Ethical Review Board of the Zhongshan Ophthalmic Centre (ZOC), and the Research Governance Committee of Moorfields Eye Hospital approved the study protocol. The study adhered to the tenets of the Helsinki Declaration and written informed consent was obtained from all subjects.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available upon reasonable request.
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