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Determinants of corneal endothelial cell loss after sulcus placement of Ahmed and Baerveldt drainage device surgery
  1. Yumiko Murakami1,
  2. Kazuyuki Hirooka1,
  3. Yuki Yuasa1,
  4. Hideaki Okumichi1,
  5. Kana Tokumo1,
  6. Reo Kawano2,
  7. Yoshiaki Kiuchi1
  1. 1Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan
  2. 2Centre For Integrated Medical Research, Hiroshima University Hospital, Hiroshima, Japan
  1. Correspondence to Kazuyuki Hirooka, Department of Ophthalmology and Visual Science, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan;khirooka9{at}


Aim In patients who underwent multiple intraocular surgeries, we evaluated determinants of decreased corneal endothelial cell density (CECD) after sulcus placement following Ahmed and Baerveldt drainage device surgery.

Methods We retrospectively reviewed consecutive patients with glaucoma who underwent sulcus placement with an Ahmed glaucoma valve or a Baerveldt glaucoma implant. We compared presurgical and postsurgical CECD and risk factors for decreased CECD.

Results We examined 41 eyes of 41 patients. Postsurgical CECD measurements were assessed 2.0±1.0 times during a median follow-up period of 28 months. The mean intraocular pressure (IOP) decreased from 28.4±11.6 mmHg to 12.2±5.3 mmHg 24 months after the operation. At 24 months, CECD decreased 14.6±5.4% after considering the variability in the number and time points of CECD determinations. History of prior surgery and higher preoperative IOP were significantly associated with a trend for a time-dependent decrease in CECD.

Conclusions Risk factors for decreased CECD after sulcus placement during Ahmed and Baerveldt drainage device surgery included the number of previous intraocular surgeries and higher presurgical IOP.

  • Glaucoma
  • Intraocular pressure
  • Treatment Surgery
  • Cornea

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  • Contributors Design: KH; conduct of the study: KH; collection: YM, YY; management: KH; analysis: RK, interpretation of data: KH, preparation: KH, review: KH, YK, approval of the manuscript: KH, YM, YY, HO, KT, RK, YK.

  • Funding This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (26462689).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval This study was approved by the Institutional Review Board of Hiroshima University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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