Background/Aims To evaluate the clinical outcomes of the systemic re-esterified triglyceride (rTG) form of omega-3 fatty acids in patients with dry eye symptoms after cataract surgery.
Methods This prospective comparative cohort study comprised 66 patients complaining of new-onset non-specific typical dry eye 1 month after uncomplicated cataract surgery. Subjects were randomly allocated into control and omega-3 groups based on administration of the systemic rTG form of omega-3 fatty acids for 2 months, in addition to use of artificial teardrop. Ocular surface parameters (Schirmer’s test, tear break-up time, corneal staining score and matrix metalloproteinase-9 (MMP-9)) and subjective questionnaire results (Ocular Surface Disease Index (OSDI)) and Dry Eye Questionnaire [DEQ]) for dry eye were evaluated before and after omega-3 supplementation.
Results Two months after omega-3 supplementation, the Oxford score was lower in the omega-3 group than in the control group. There was an improvement of subjective symptom scores of OSDI and DEQ in the omega-3 group (both p<0.05). The ratio of increasing MMP-9 level in the omega-3 group was lower than that in the control group (p=0.027).
Conclusion The rTG form of omega-3 supplementation might be related to reduction of ocular surface inflammation rather than secretion of tears, and it might be effective for non-specific typical dry eye after uncomplicated cataract surgery.
Trial registration Number NCT04411615.
- Ocular surface
- Clinical Trial
- Treatment Medical
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JP and Y-SY contributed equally as co-first authors.
DHL and T-YC contributed equally as co-corresponding authors.
Contributors DHL and T-YC contributed to conception and design of the study and Y-SY, GH, KS, DHL and T-YC conducted the study; (JP, Y-SY, ES, GH and KS) contributed to collection, management and interpretation of data; Y-SY contributed to data analysis; JP, Y-SY and ES contributed to writing of the article; DHL and T-YC contributed to preparation, review and approval of the manuscript. JP and Y-SY contributed equally to the manuscript as the co-first authors. DHL and T-YC contributed equally to the manuscript as the co-corresponding authors.
Funding This work was supported by a grant of Samsung Medical Center Research and Development Grant (#SMO120066) and a National Research Foundation of Korea grant funded by the Korean government’s Ministry of Education (NRF-2020R1A2C2014139; Seoul, Korea) which was received by T-YC.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement No data are available.
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