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Foveal cone count reduction in resolved endophthalmitis: an adaptive optics scanning laser ophthalmoscopy (AO-SLO)-based prospective pilot study
  1. Vivek Pravin Dave1,
  2. Sanjay Kumar2,
  3. Yasmeen Mulani3,
  4. Ashutosh Richhariya4,
  5. Rajeev Reddy Pappuru1,
  6. Taraprasad Das1
  1. 1Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, India
  2. 2Engineering Department, LV Prasad Eye Institute, Hyderabad, India
  3. 3Brien Holden Institute of Optometry and Vision Sciences, LV Prasad Eye Institute, Hyderabad, India
  4. 4Ophthalmic Engineering Group–Srujana Centre for Innovation, LV Prasad Eye Institute, Hyderabad, India
  1. Correspondence to Vivek Pravin Dave, Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, India; vivekoperates{at}yahoo.co.in

Abstract

Aim To report the foveal cone count in eyes with resolved endophthalmitis vis-à-vis normal fellow eyes using an indigenous adaptive optics scanning laser ophthalmoscopy (AO-SLO).

Methods In a prospective cross-sectional comparative pilot study, we recruited patients with resolved endophthalmitis in one eye (study eye) and a normal fellow eye (control eye). Collected data included measurement of the best-corrected visual acuity (BCVA), spectral-domain optical coherence tomography (OCT) imaging and AO-SLO imaging and cone counting at the fovea in both eyes.

Results The study included 12 eyes of 6 patients. The mean age was 51.66±11.97 years (median 56 years). BCVA in all control eyes was 20/20 (logarithm of the minimum angle of resolution (LogMAR) 0), and in the study, eyes was 0.21±0.13 (median 0.19, Snellen 20/30; p=0.001; 95% CI −0.39 to −0.09). The follow-up was 18.66±12.32 (median 20 months). The cone count at the fovea in the control eye was 4356.33±1993.93 (median 4498), and in the study eye, it was 2357.16±1541.17 (median 2187.5; p=0.03; 95% CI −3556 to −1082).

Conclusions Eyes with resolved endophthalmitis with near-normal vision have reduced number of foveal cones even in absence of OCT-detected gross structural changes.

Translational Relevance The current work describes the application of cellular-level imaging technique called adaptive optics scanning laser ophthalmoscopy (AO-SLO) to the clinical condition of resolved endophthalmitis. The study of retinal cell biology at the cellular level is possible using the emerging technology of AO-SLO. This new investigative modality that has the potential to image the retina at the cellular level until the photoreceptors is more likely to unravel the pathophysiology of a variety of retinal diseases.

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Footnotes

  • Contributors VPD and SK conceptualised the project. VPD procured relevant clearances and wrote the manuscript draft. YM, RP, AR and TD revised the manuscript and helped with the patient flow.

  • Funding This study was supported by funding by the Hyderabad Eye Research Foundation.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Not applicable.

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