Article Text
Abstract
Background/Aims To evaluate quantitative changes in the foveal avascular zone (FAZ) area after glaucoma surgery using swept-source optical coherence tomography angiography (SS-OCTA).
Methods Fifty-four consecutive patients with primary open-angle glaucoma (POAG) who met the inclusion criteria and underwent unilateral glaucoma surgery to reduce intraocular pressure (IOP) between April 2018 and July 2019.
Eyes underwent IOP-lowering glaucoma surgery and their fellow (non-surgical) eyes were included. OCTA of the macula was performed in both eyes before glaucoma surgery and 3 months postoperatively. Two blinded examiners reviewed the image quality. Within- and between-group comparisons of the FAZ area and correlation of the FAZ area with age, IOP, central sensitivity and clinical variables.
Results The mean (±SD) age was 66.7±11.3 years. After surgery, the IOP and FAZ area significantly decreased from 22.1±9.5 mmHg to 10.3±3.5 mmHg and from 0.485±0.193 mm2 to 0.446±0.174 mm2, respectively (both p<0.001). Conversely, in the non-surgery group, the preoperative and postoperative mean FAZ areas (0.398±0.119 mm2 and 0.396±0.110 mm2, respectively) did not significantly differ (p=0.469). Change in the FAZ area significantly correlated with the preoperative FAZ area, preoperative foveal sensitivity and change in IOP (all p<0.05).
Conclusions The FAZ area is decreased with IOP-lowering surgery in patients with POAG, and change in the FAZ area was significantly correlated with both preoperative foveal sensitivity and change in IOP.
- Imaging
- Glaucoma
- Anatomy
- Retina
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Footnotes
Contributors Design and conduct of the study: TS, YY and KS. Data collection: TS, JK, YY, IM, HI (Hirokazu Ishii), HI (Hisashi Ibuki). Analysis and interpretation of data: TS, JK, RNW and KS. Writing: TS. Critical revision: TS, RNW and KS. Approval of the manuscript: TS, JK, RNW, IM, YY, HI (Hirokazu Ishii), HI (Hisashi Ibuki) and KS.
Funding This study was supported in part by the Japan Society for the Promotion of Science grant (KAKENHI grant number 19K09976), Saitama Medical University (01E107) and the National Eye Institute (R01 EY029058).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available upon reasonable request.
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