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Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography
  1. Liqin Gao1,
  2. Jie Wang2,
  3. Qisheng You2,
  4. Yukun Guo2,
  5. Christina J Flaxel2,
  6. Thomas S Hwang2,
  7. David Huang2,
  8. Yali Jia2,
  9. Steven T Bailey2
  1. 1Ophthalmology, Beijing Tongren Eye Center, Beijing, China
  2. 2Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA
  1. Correspondence to Dr Steven T Bailey, Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA; bailstev{at}ohsu.edu

Abstract

Objective To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA).

Methods and analysis In this prospective cross-sectional single centre study, eyes with treatment-naïve EAMD underwent macular 3×3 mm OCTA with AngioVue system. OCTA scans were analysed and processed including three-dimensional projection artefact removal, retinal layer semi-automated segmentation and en face angiogram generation. Automated quantification of extrafoveal (excluding the central 1 mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), respectively.

Results Nineteen eyes with EAMD and 19 age-matched healthy control eyes were included. There was no significant difference between the EAMD and control eyes in terms of age, sex, axial length and mean ocular perfusion pressure (all p>0.05). Compared with control eyes, EAMD eyes had significantly larger EAA in SVC (median 0.125 vs 0.059 mm2, p=0.006), ICP (0.016 vs 0.000 mm2, p=0.004) and DCP (0.033 vs 0.000 mm2, p<0.001).

Conclusion PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses.

  • imaging
  • macula
  • neovascularisation
  • retina
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Footnotes

  • Presented at The abstract was submitted to and will be presented at the Association for Research in Vision and Ophthalmology 2020 Annual Meeting, Baltimore, USA.

  • Contributors LG: Assembly of data, data analysis and interpretation and manuscript writing. JW: Assembly of data, data analysis and interpretation and manuscript preparation. QSY: Conception and design, assembly of data, data analysis and interpretation and manuscript writing. YG: Assembly of data, data analysis and interpretation and manuscript preparation. CF: Collection of data and manuscript preparation. TSH: Collection of data and manuscript preparation. DH: Data analysis and interpretation and manuscript preparation. YJ: Conception and design, collection and/or assembly of data, data analysis and interpretation and manuscript writing. SB: Conception and design, collection and/or assembly of data, data analysis and interpretation and manuscript writing.

  • Funding The study was supported by grants R01 EY024544, R01 EY027833 and P30 EY010572 from the National Institutes of Health, an unrestricted departmental funding grant and William & Mary Greve Special Scholar Award from Research to Prevent Blindness, New York.

  • Disclaimer The funding source had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication.

  • Competing interests Oregon Health & Science University (OHSU) and Drs Huang and Jia have a significant financial interest in Optovue, a company that may have a commercial interest in the results of this research and technology. These potential conflicts of interest have been reviewed and managed by OHSU.

  • Patient consent for publication Not required.

  • Ethics approval The study was approved by the institutional review board at Oregon Health & Science University and performed in accordance with the tenets of the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement No data are available. Not applicable.

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