Objective To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA).
Methods and analysis In this prospective cross-sectional single centre study, eyes with treatment-naïve EAMD underwent macular 3×3 mm OCTA with AngioVue system. OCTA scans were analysed and processed including three-dimensional projection artefact removal, retinal layer semi-automated segmentation and en face angiogram generation. Automated quantification of extrafoveal (excluding the central 1 mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), respectively.
Results Nineteen eyes with EAMD and 19 age-matched healthy control eyes were included. There was no significant difference between the EAMD and control eyes in terms of age, sex, axial length and mean ocular perfusion pressure (all p>0.05). Compared with control eyes, EAMD eyes had significantly larger EAA in SVC (median 0.125 vs 0.059 mm2, p=0.006), ICP (0.016 vs 0.000 mm2, p=0.004) and DCP (0.033 vs 0.000 mm2, p＜0.001).
Conclusion PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses.
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Presented at The abstract was submitted to and will be presented at the Association for Research in Vision and Ophthalmology 2020 Annual Meeting, Baltimore, USA.
Contributors LG: Assembly of data, data analysis and interpretation and manuscript writing. JW: Assembly of data, data analysis and interpretation and manuscript preparation. QSY: Conception and design, assembly of data, data analysis and interpretation and manuscript writing. YG: Assembly of data, data analysis and interpretation and manuscript preparation. CF: Collection of data and manuscript preparation. TSH: Collection of data and manuscript preparation. DH: Data analysis and interpretation and manuscript preparation. YJ: Conception and design, collection and/or assembly of data, data analysis and interpretation and manuscript writing. SB: Conception and design, collection and/or assembly of data, data analysis and interpretation and manuscript writing.
Funding The study was supported by grants R01 EY024544, R01 EY027833 and P30 EY010572 from the National Institutes of Health, an unrestricted departmental funding grant and William & Mary Greve Special Scholar Award from Research to Prevent Blindness, New York.
Disclaimer The funding source had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication.
Competing interests Oregon Health & Science University (OHSU) and Drs Huang and Jia have a significant financial interest in Optovue, a company that may have a commercial interest in the results of this research and technology. These potential conflicts of interest have been reviewed and managed by OHSU.
Patient consent for publication Not required.
Ethics approval The study was approved by the institutional review board at Oregon Health & Science University and performed in accordance with the tenets of the Declaration of Helsinki.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement No data are available. Not applicable.
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