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Comparing the usefulness of a new algorithm to measure visual field using the variational Bayes linear regression in glaucoma patients, in comparison to the Swedish interactive thresholding algorithm
  1. Hiroshi Murata1,
  2. Ryo Asaoka1,2,3,
  3. Yuri Fujino1,2,4,
  4. Masato Matsuura1,5,
  5. Kazunori Hirasawa5,
  6. Satoshi Shimada6,
  7. Nobuyuki Shoji5
  1. 1 Department of Ophthalmology, The University of Tokyo, Tokyo, Japan
  2. 2 Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan
  3. 3 Seirei Christopher University, Hamamatsu, Japan
  4. 4 Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan
  5. 5 Department of Ophthalmology, Kitasato University Graduate School of Medical Sciences, Kanagawa, Japan
  6. 6 Kowa Company, Ltd, Nagoya, Japan
  1. Correspondence to Dr Ryo Asaoka, Department of Ophthalmology, Tokyo University, Bunkyo-ku 112-0001, Japan; ryoasa0120{at}


Background/aims We previously reported that the visual field (VF) prediction model using the variational Bayes linear regression (VBLR) is useful for accurately predicting VF progression in glaucoma (Invest Ophthalmol Vis Sci. 2014, 2018). We constructed a VF measurement algorithm using VBLR, and the purpose of this study was to investigate its usefulness.

Method 122 eyes of 73 patients with open-angle glaucoma were included in the current study. VF measurement was performed using the currently proposed VBLR programme with AP-7700 perimetry (KOWA). VF measurements were also conducted using the Swedish interactive thresholding algorithm (SITA) standard programme with Humphrey field analyser. VF measurements were performed using the 24–2 test grid. Visual sensitivities, test–retest reproducibility and measurement duration were compared between the two algorithms.

Result Mean mean deviation (MD) values with SITA standard were −7.9 and −8.7 dB (first and second measurements), whereas those with VBLR-VF were −8.2 and −8.0 dB, respectively. There were no significant differences across these values. The correlation coefficient of MD values between the 2 algorithms was 0.97 or 0.98. Test–retest reproducibility did not differ between the two algorithms. Mean measurement duration with SITA standard was 6 min and 02 s or 6 min and 00 s (first or second measurement), whereas a significantly shorter duration was associated with VBLR-VF (5 min and 23 s or 5 min and 30 s).

Conclusion VBLR-VF reduced test duration while maintaining the same accuracy as the SITA-standard.

  • field of vision
  • glaucoma

Statistics from


  • Contributors RA, HM and SS researched literature and conceived the study. RA, HM and NS were involved in protocol development and gaining ethical approval. All authors were involved in patient recruitment and data analysis. RA wrote the first draft of the manuscript. All authors reviewed and edited the manuscript and approved the final version of the manuscript.

  • Funding Supported in part by Japan Science and Technology Agency (JST) CREST (RA, HM), Grants 00768351 (MM), 20 768 254 (YF), 25 861 618 (HM) and 19H01114, 18KK0253, and 26 462 679 (RA) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, grant from the University of Tokyo Gap Fund ProgramProgramme (no grant number), and grants from Suzuken Memorial Foundation (no grant number) and Taiju Life Social Welfare Foundation (Mitsui Life Social Welfare Foundation) (no grant number).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by the Research Ethics Committee of the Graduate School of Medicine and Faculty of Medicine at the University of Tokyo.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request.

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