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Cystoid macular oedema after descemet membrane endothelial keratoplasty
  1. Damien Guindolet1,
  2. Odile Huynh1,
  3. Gilles C Martin1,
  4. Hugo Disegni1,
  5. Georges Azar1,
  6. Isabelle Cochereau1,2,3,
  7. Eric Gabison1,2,3
  1. 1Ophthalmology—Pr Cochereau, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
  2. 2Université de Paris, Paris, France
  3. 3Ophthalmology—Pr Cochereau, Bichat Claude-Bernard Hospital, Paris, Île-de-France, France
  1. Correspondence to Professor Eric Gabison, Corneal and External Diseases, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France; egabison{at}


Aims To determine the incidence and risk factors of cystoid macular oedema (CMO) following descemet membrane endothelial keratoplasty (DMEK) with or without combined cataract surgery (triple-DMEK).

Methods We reviewed the records of patients who underwent DMEK surgery alone or triple-DMEK performed at the Rothschild Foundation Hospital (Paris, France) between January 2019 and March 2020. Patients with pre-existing CMO observed on the preoperative macular optical coherence tomography (OCT) were excluded. Spectral-domain OCT was performed in patients with postoperative visual impairment. Data regarding comorbidities, intraoperative characteristics and postoperative treatments or complications were collected and analysed. Univariate and multivariate analyses were performed.

Results Twenty three of 246 eyes (9.36%) developed clinically significant (cs)-CMO after DMEK. Triple-DMEK was not associated with a higher risk to develop CMO (12.2% in DMEK alone and 6.1% in triple-DMEK). Pseudophakic bullous keratopathy (PBK ; 39.1% vs 9%; OR=3.5 (1.0 to 11.8), p=0.045) and epiretinal membrane (ERM; 39.1% vs 7.7%; OR=10.5 (3.4 to 32.3), p<0.001) were more frequently observed in patients who developed CMO. The occurrence of hyphaema during surgery was statistically associated with postoperative CMO (13% vs 1.3%; OR=7.1 (1.0 to 48.8) p=0.045). Peroperative epithelial debridement was statistically associated with postoperative CMO (65.2% vs 33.2%, p=0.005), but only in univariate analysis.

Conclusions We identified a clinically significant CMO incidence of 9.35% after DMEK. Patients with a history of ERM, PBK and intraoperative hyphaema may be at risk of developing CMO after DMEK surgery and should be monitored.

  • cornea

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  • DG and OH are joint first authors.

  • Contributors DG and OH equally as co-first authors. Authorship: conception of the work (DG, GCM, IC, EG), data acquisition (DG, OH, HD), data analysis (DG, OH, HD, EG). Drafting the work (DG, OH, HD, EG) or revising it (DG, GCM, GA, IC, EG) critically for important intellectual content; final approval of the version to be published (DG, OH, GCM, HD, GA, IC, EG). Agreement to be accountable (DG, OH, GCM, HD, GA, IC, EG) for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. DG acts as the guarantor of the study.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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