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Change of peripapillary retinal nerve fiber layer and choroidal thickness during 4-year myopic progress: Boramae Myopia Cohort Study Report 4
  1. Martha Kim1,2,
  2. Kyoung Min Lee3,4,
  3. Ho-Kyung Choung3,4,
  4. Sohee Oh5,
  5. Seok Hwan Kim3,4
  1. 1Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, the Republic of Korea
  2. 2Sensory Organ Research Institute, Dongguk University Ilsan Hospital, Goyang, the Republic of Korea
  3. 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, the Republic of Korea
  4. 4Department of Ophthalmology, Seoul National University Boramae Hospital, Seoul, the Republic of Korea
  5. 5Department of Biostatistics, Seoul National University Boramae Hospital, Seoul, the Republic of Korea
  1. Correspondence to Dr Seok Hwan Kim, Department of Ophthalmology, Seoul National University College of Medicine, Seoul, the Republic of Korea; xcski{at}hanmail.net

Abstract

Aims To investigate the longitudinal changes of peripapillary retinal nerve fibre layer (RNFL) and choroidal thickness during myopic axial elongation.

Methods Peripapillary RNFL and choroidal thickness were prospectively evaluated by spectral-domain optical coherence tomography (SD-OCT) in 46 eyes of 23 myopic children over the course of 4 years. Using serial OCT images acquired based on a fixed scan circle in the glaucoma progression analysis mode, general and sectoral RNFL thicknesses were acquired at the same position and the angular location of the peak was measured. The peripapillary choroidal thickness likewise was measured at eight positions in serial OCT images.

Results The mean age at the baseline was 9.6±1.7 years. The mean axial length increased from 24.80±1.28 mm to 25.64±1.35 mm. The global peripapillary RNFL thickness was 98.54±12.06 µm at baseline. The global and sectoral RNFL thicknesses did not change during the 4 years. The angular location of RNFL peaks was also stable and was located in the superotemporal (64.18±10.85°) and inferotemporal (293.98±11.62°) sectors. The global peripapillary choroidal thickness was 145.40±28.67 µm at the baseline. The global and sectoral choroidal thicknesses did not change during the 4 years.

Conclusions The peripapillary RNFL and choroidal thicknesses as well as the locations of the RNFL peaks had been preserved, during the 4-year follow-up on myopic children, when traced and measured from the same location.

  • Retina
  • Choroid
  • Optic Nerve
  • Optics and Refraction

Data availability statement

All data relevant to the study are included in the article or uploaded as supplementary information. Not applicable.

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Data availability statement

All data relevant to the study are included in the article or uploaded as supplementary information. Not applicable.

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Footnotes

  • MK and KML are joint first authors.

  • Contributors MK, KML and SHK: study design and data interpretation; KML, HC and SHK: data acquisition; MK, KML and SO: data analysis; MK and KML: manuscript preparation and MK and SHK: final approval of manuscript; SHK: guarantor.

  • Funding This work was supported by a clinical research grant in aid from the Seoul National University Boramae Medical Center (grant no. 04-2021-0003) and the Dongguk University Research Fund of 2019.

  • Disclaimer The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.