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Association of baseline optical coherence tomography angiography with the development of glaucomatous visual field defects in preperimetric glaucoma eyes
  1. Jin Yeong Lee1,
  2. Joong Won Shin2,
  3. Anna Lee1,
  4. Min Su Baek1,
  5. Michael S Kook2
  1. 1Department of Ophthalmology, Asan Medical Center, Seoul, Korea (the Republic of)
  2. 2Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea (the Republic of)
  1. Correspondence to Dr Michael S Kook, Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, Korea (the Republic of); mskook{at}amc.seoul.kr

Abstract

Aims To evaluate whether baseline vessel density (VD) parameters derived from optical coherence tomography angiography (OCT-A) is associated with the development of glaucomatous visual field (VF) defects in preperimetric glaucoma (PPG) patients.

Methods One eye from each of 200 consecutive PPG patients with a normal standard automated perimetry and OCT-A at baseline was retrospectively analysed. OCT-A was used to measure the circumpapillary VD (cpVD) and the parafoveal and perifoveal VD. The retinal nerve fibre layer (RNFL) and macular ganglion cell-inner plexiform layer thicknesses were measured as reference standards. Two patient groups were stratified based on the development of repeatable glaucomatous VF loss. A Cox proportional hazards model was constructed to determine the predictive ability of OCT-A parameters for VF defects. The correlation between these baseline OCT-A parameters and the rate of global VF sensitivity loss (dB/year) was calculated using linear regression analysis.

Results During a 3.1-year average follow-up period, 18 eyes (9.0%) developed glaucomatous VF defects. At baseline, the lower inferior temporal cpVD (HR (95% CI)=0.934 (0.883 to 0.988); p=0.017) and thinner inferior RNFL (HR (95% CI)=0.895 (0.839 to 0.956); p=0.001) were predictive of glaucomatous VF loss. A lower inferior temporal cpVD and thinner RNFL at baseline were associated with faster rate of global VF sensitivity loss (β=0.015; p=0.001).

Conclusion In PPG eyes, a lower baseline inferior temporal cpVD is significantly associated with glaucomatous VF defect development and a faster rate of global VF loss.

  • Glaucoma
  • Field of vision
  • Imaging

Data availability statement

Data are available on reasonable request.

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Data availability statement

Data are available on reasonable request.

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Footnotes

  • Contributors Conception and design: MSK. Acquisition, analysis and interpretation of data: JYL, JWS and MSK Drafting of the manuscript: JYL and MSK. Critical revision of the manuscript for important intellectual content: all authors. Statistical analysis: JYL, AL, MSB and JWS. Supervision: MSK, guarantor: MSK.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.