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Choriocapillaris flow features in children with myopic anisometropia
  1. Zhihao Jiang1,
  2. Wu Bo2,
  3. Zhengfei Yang1,
  4. Xiaoling Luo1,
  5. Yao Ni1,
  6. Junwen Zeng1
  1. 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangzhou, Guangdong, China
  2. 2South China Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China
  1. Correspondence to Prof. Junwen Zeng, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangzhou, Guangdong, China; zengjunw{at}mail.sysu.edu.cn; Dr Yao Ni; niyao{at}gzzoc.com

Abstract

Aims To examine differences between the eyes in choriocapillaris perfusion and choroidal thickness in children with myopic anisometropia.

Methods In this observational and prospective study, 46 children with myopic anisometropia were enrolled. Choriocapillaris perfusion parameters, including the percentage of flow voids, the total number of flow voids and the average flow void area were obtained by optical coherence tomography angiography (OCTA). The OCTA image was divided into a 1 mm-diameter central circle (C1) and a 2.5 mm-diameter annulus (without the inner central 1 mm circle, C1-2.5). Both C1 and C1-2.5 are centred on the foveola. The C1-2.5 was divided into nasal (N1-2.5), temporal (T1-2.5), inferior (I1-2.5) and superior (S1-2.5) areas. Differences in these parameters in different regions between eyes were analysed.

Results There were no significant differences in the percentage of flow voids and the average flow void area between the fellow eyes. The total number of signal voids was significantly higher in the less myopic eyes in C1-2.5 (p=0.032), S1-2.5 (p=0.008) and N1-2.5 (p=0.019). Changes in spherical equivalent refraction and axial length were both correlated with the changes in the total number of flow voids in N1-2.5 (R=−0.431, p=0.03; R=−0.297, p=0.047).

Conclusions The choroid in the macular region becomes thinner and the total number of flow voids in the nasal macular region decreased with the amplitude of myopia. This suggests that a decrease in total number of flow voids may indicate an early change in myopia.

  • Imaging
  • Choroid
  • Optics and Refraction

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Data availability statement

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Footnotes

  • ZJ, WB and ZY are joint first authors.

  • Contributors Design of the study (JWZ,YN,ZHJ), the conduct of the study, data collection, analysis and interpretation (ZFY, WB, XLL), writing the manuscript (ZHJ, WB, YN), critical revision of the manuscript (YN, ZFY, JWZ), supervision (YN, JWZ). ZHJ, WB and ZFY contributed equally to this manuscript.

    JWZ is guarantor.

  • Funding This study was supported by the Science and Technology Program of Guangzhou of China (20210210145) and the Natural Science Foundation of Guangdong Province, China (2020A1515010829; 2019A1515010077).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.