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Posner-Schlossman Syndrome European Study Group: study protocol and baseline patients characteristics of a multicentre study
  1. Emanuela Interlandi1,2,
  2. Luca Cimino3,4,
  3. Massimo Accorinti5,
  4. Elisabetta Miserocchi6,
  5. Loredana Latanza2,
  6. Pia Allegri7,
  7. Paolo Mora8,
  8. Alex Fonollosa9,
  9. Alfredo Adan10,
  10. Carlos Pavesio11,12,
  11. Rocco De Marco1,
  12. Stefano A Gandolfi8,
  13. Paolo Nucci13,
  14. Marco De Luca1,
  15. Fabrizio Gozzi4,
  16. Giacomo Visioli5,
  17. Federico Rissotto6,
  18. Roberta Rissotto7,
  19. Carlo Bellucci8,
  20. Josè Manuel Cachero9,
  21. Francesco Pellegrini14,
  22. Gaia Li Calzi13,
  23. Maite Sainz de la Maza10,
  24. Pasquale Cirillo1,
  25. Valentina Mastrofilippo4,
  26. Matteo Sacchi15,16
  1. 1Uveitis Center, Department of Ophthalmology, Ospedale del Mare, ASL Napoli 1-centro, Naples, Italy
  2. 2Uveitis Center, Centro Uveiti Napoli, Naples, Italy
  3. 3Surgery, Medicine, Dentistry and Morphological Science with interest in Transplants, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy
  4. 4Ocular Immunology Unit, Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy
  5. 5Ocular Immunovirology Service, Department of Ophthalmology, University of Rome La Sapienza, Rome, Italy
  6. 6Department of Ophthalmology, San Raffaele Scientific Institute, Università Vita e Salute, Milan, Italy
  7. 7Ocular Inflammatory Diseases Referral Center, Rapallo Hospital, Rapallo, Italy
  8. 8Ophthalmology, University of Parma, Parma, Italy
  9. 9Ophthalmology, Cruces University Hospital, University of the Basque Country, Bilbao, Spain
  10. 10Ophthalmology Department, Institut Clinic de Barcelona, Autonoma University, Barcelona, Spain
  11. 11Moorfields Eye Hospital NHS Foundation Trust, London, UK
  12. 12UCL Institute of Ophthalmology, London, UK
  13. 13Ophthalmology, University Eye Clinic, San Giuseppe Hospital, IRCCS Multimedica, Milan, Italy
  14. 14Ophthalmology, Ospedale Santa Maria degli Angeli di Pordenone, Pordenone, Italy
  15. 15Ophthalmology, University of Sassari, Sassari, Italy
  16. 16Ophthalmology, Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy
  1. Correspondence to Dr Emanuela Interlandi, ASL Napoli 1-centro, Uveitis Center, Ophthalmology, Ospedale del Mare, Napoli, Campania, Italy; dott.emanuelainterlandi{at}


Background The aim of the Posner-Schlossman Syndrome European Study Group (PSS-ESG) is to acquire a comprehensive dataset of European patients with PSS. Here, we present the first report on the study protocol and the clinical findings of the patients at baseline.

Methods The PSS-ESG is a retrospective, multicentre study designed to evaluate patients with PSS. The study, designed and driven by a European Expert Committee includes three datasets: (1) the baseline, (2) the follow-up and (3) the intraocular pressure (IOP)/glaucoma dataset.

Results A total of 11 centres adhered to the PSS-ESG and 107 patients were included (68 males, 39 females) mostly Caucasian (93.4%). At uveitis onset, the patient’s age ranged between 11 and 76 years, (mean age: 42±15 years).

Best-corrected visual acuity was >0.5 in 80.3% of the eyes, IOP was >40 mm Hg in 44% of the eyes. Keratic precipitates were found in 78.5% of the eyes. No flare or cells in anterior chamber were detected in 56% and 53% of the cases, respectively. PCR analysis on aqueous sample was positive for cytomegalovirus-DNA in 50.6% out of the 81 tested patients.

Conclusions The PSS-ESG is the first multicentre study aimed to collect a comprehensive dataset of patients with PSS in non-Asian countries. A middlde-aged Caucasian male with a low-grade anterior chamber inflammation, keratic precipitates, preserved visual acuity and marked increased in IOP seemed to be the standard PSS patient across the 11 uveitis and glaucoma centres participating in the PSS-ESG.

  • Inflammation
  • Ocular Hypertension
  • Immunology
  • Glaucoma
  • Infection

Data availability statement

All data relevant to the study are included in the article or uploaded as online supplemental information.

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Data availability statement

All data relevant to the study are included in the article or uploaded as online supplemental information.

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  • X @alex_fonollosa

  • EI and MS contributed equally.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.