46 e-Letters

published between 2010 and 2013

  • Significant design flaws bias the results in favour of aflibercept
    Andrew Zambanini

    Dr Cho and colleagues present data on a very small cohort of patients with wet AMD that have switched treatment from either bevacizumab or ranibizumab to aflibercept. Of note, this subgroup comprised approximately 8% of the total number of patients switched to aflibercept.

    Any retrospective review is likely to be heavily biased by the anticipated 'treatment benefit' of a new therapy particularly if, as in this ca...

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  • The long-term psychosocial impact of correction surgery for adults with strabismus
    Gerald McGwin

    We read with interest Jackson and Morris's response to our letter.

    The author's indicated that it was not possible to conduct a repeated measures ANOVA using SPSS. However, SPSS provides several ways to analyze repeated measures ANOVA through the general linear model command. There are several excellent texts that illustrate how to conduct an ANOVA using a repeated measures design in the SPSS environment....

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  • Re:Non-inferiority or superiority?
    Etsuko Takamura

    We would like to thank Dr. Geitzenauer for his comments and concerns regarding our study.

    As he has pointed out, in a non-inferiority study there is potential for bias which may narrow down the difference in efficacy. Therefore, conducting a superiority study simultaneously would be difficult, unless sufficient quality is ensured during study planning, conduct as well as data analysis.

    However, our st...

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  • Non-inferiority or superiority?
    Wolfgang Geitzenauer

    Dear editors,

    Takamura et al. report in a recent edition of the BJO about a "multi- center, randomised, double-masked, parallel study" which leads to both a non-inferiority and a superiority claim of the ophthalmic solution being tested (diquafosol ophthalmic solution).(Reference 1) From a methodological standpoint, the conclusions reached by the authors are not in agreement with current accepted standards in th...

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  • Risk of cataract for patients with diabetes mellitus
    Tomoyuki Kawada

    I read the paper entitled "Risk of selected eye diseases in people admitted to hospital for hypertension or diabetes mellitus: record linkage studies" with interest. It elucidated that diabetes mellitus has a risk of several ocular diseases with significance using two big epidemiological data. However, I have two queries on their outcome by selecting the association between cataract and diabetes mellitus.


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  • Improving access to eye care in a remote region in Western Kenya
    Rebecca Nightingale

    Using a chart review, Nyamori and colleagues estimated the incidence of retinoblastoma in Kenya to be 1:17,000 live births, similar to global estimates.1 They observed that late presentation was common, often attributed to poor awareness or socioeconomic barriers which hinder access to care. We describe a recent project to improve access to eye care for people living in Western Kenya.

    IcFEM Dreamland Mission Hos...

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  • Response to `Clinical factors associated with malignancy and HIV status in patients with ocular surface squamous neoplasia at Kililmanjaro Christian Medical Centre, Tanzania'
    Dr. Jinesh M. Shah

    Dear Author,

    We read your paper entitled `Clinical factors associated with malignancy and HIV status in patients with ocular surface squamous neoplasia at Kililmanjaro Christian Medical Centre, Tanzania' with much interest. It was an interesting insight into the characteristics of OSSN patients in sub-saharan Africa. However, we had some queries and we hope you can share your thoughts on them.


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  • Re:Brimonidine induced uveitis: Extent of the problem?
    Josephine C Richards

    The authors thank the respondent for the observations and comments. Most of our patients were referred to us by other ophthalmologists. Unfortunately, as tertiary referral practitioners to the wider ophthalmic community (uveitis: JCR, glaucoma: WHM and DD) we have no way of knowing how many patients in our community are on brimonidine or how many cases of brimonidine induced uveitis may be seen by other consultants. We ag...

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  • Brimonidine induced uveitis: Extent of the problem?
    Khawaja K Shoaib

    Article "Brimonidine (Alphagan) associated anterior uveitis" by McKnight CM et al1 is informative. Cessation of brimonidine eye drops resulted in improvement of uveitis in five cases. This case series has produced further evidence that brimonidine may be responsible for uveitis/ raised IOP in some cases. However a critic may still argue the two events to be coincidental. Unfortunately we have only a few anti glaucoma drug...

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  • Re:Re:Efficacy of Silicone Punctal Plugs in Children
    Ken K Nischal

    We thank Dr Shoaib for his comments. In the results we clearly state 'The indication for insertion was based on the presence of ocular surface changes and poor tear film meniscus, with a previous unsuc- cessful management by lubrication and topical medication alone. Overall, 18 of the 25 patients had a concurrent systemic disorder (table 1).' Schirmer's test is , we believe , a poor test for dry eye in children. It often r...

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