190 e-Letters

published between 2005 and 2008

  • Authors' reply
    Gerald McGwin Jr.
    Dear Editors

    We appreciate Dr. Kadyan’s letter regarding our study “Non-arteritic anterior ischaemic optic neuropathy and presumed sleep apnoea syndrome screened by the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ)” [1]. He requests clarification on several issues and, to the best of our ability we will attempt to respond to each in turn. Regarding the proportion of cases and controls diagnosed with glauco...

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  • Authors' response
    Ludwig M. Heindl

    Dear Editors

    We thank Dr Munier and Dr Satgé for their interest in our work on “Aggressive metastasising adenocarcinoma of the retinal pigment epithelium with trisomy 21” [1] and welcome the opportunity to respond to their comments.

    We are in agreement with Dr Munier and Dr Satgé that life-threatening ophthalmic tumours must be kept in mind while taking care of patients with Down syndrome. Despite an imp...

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  • Is a field every 4 month a significant improvement over a field every 6 months?
    Albert Alm

    Dear Editors

    How often should we do visual fields in the first 2 years? Chauhan and co-workers [1] recommend 3 visual fields per year. It will have an 80% power of detecting a rate of loss of 2 dB/year in an eye with moderate variability. Is this a significant improvement over 2 fields per year? In order to answer that we should look at the efficacy of increasing the frequency of field examinations versus prolongin...

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  • Vitreous buffering capacity as a mechanism for silicone oil optic
    morteza mehdizadeh

    Vitreous buffering capacity as a mechanism for silicone oil optic neuropathy

    Dear editors

    I read with interest the article concerning silicone oil optic neuropathy by Knecht et al in October issue of BJO. In that article they suggest an active transport of silicone oil into the optic nerve as a mechanism for optic neuropathy. [1] I would like to suggest a new mechanism based on buffering capacity...

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  • OCT measurement and visual function
    Caroline J Styles

    Dear Editors

    We read with interest the study from Moutray et al[1] that found Optical Coherence Tomography (OCT) measures are not robust markers for visual function. We have looked at 20 patients with wet age related macular degeneration (AMD) and compared visual function and OCT measures using the new generation of Fourier Domain 3D OCT. We also find no significant correlation between OCT measurements of central...

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  • Awareness on eye tumours and Down syndrome
    Francis L Munier

    Dear Editor

    A metastizing adenocarcinoma of the retinal pigment epithelium in a 37-year-old man with Down syndrome (DS) has recently been reported in the British Journal of Ophthalmology [1]. In the article the authors underlined an unusual and atypical aggressive behaviour of the tumour which was the first well documented adenocarcinoma of the retinal pigment epithelium with metastases. Although solid tumours are...

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  • Author's response
    Ferdinando Bottoni

    Dear Editor

    We thank Dr Ayata for the thoughtful comments of our article. He had three questions that we would like to answer as follows:
    1) Figure 1 was quite important for the paper because it shows the exact location of the macular pigment in monkeys (courtesy of Francois Delori, PhD). We are sorry for the lack of the image in the on-line paper version but it was probably due to the PDF saving...

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  • Methylation in uveal melanoma
    Pieter A van der Velden

    Dear editor,

    Epigenetic regulation of tumor suppressor genes provides an attractive mechanism for tumors in which mutations and structural changes are rare. The latter may apply to uveal melanoma for which little is known of the genes that contribute to tumor development. In the search for genes, uveal melanoma is often compared to its counterpart in the skin, cutaneous melanoma. One of the major cuteneous melan...

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  • Re: Intraocular pressure rise during dilatation -author's reply
    George L Spaeth

    Dear Dr Radcliffe and colleagues,

    Thank you for your comments. Two cases with the exfoliation syndrome and one with pigmentary glaucoma were included in our study. As you mentioned, dilatation of the pupil often causes a rise of intraocular pressure in such cases. However, none of the three individuals in our study had a significant rise of intraocular pressure or progression of glaucoma. Sincerely, George Sp...

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  • Re: Newcastle score in intermittent exotropia -authors reply
    Michael P Clarke

    Dear Editor

    We thank Dr Kesarwani for the interest in our article.

    In response to the points raised:

    1. Inclusion criteria
    We attempted to recruit children with X(T) measuring more than 20 prism dioptres when fixing a 6 metre target, as angles under this amount are usually felt not to require treatment. However, Dr Kesarwani is correct to point out that, at the baseline assessme...

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