66 e-Letters

published between 2008 and 2011

  • The Statistical Interpretation of the Coefficient of Repeatability
    James Loughman

    Bartlett et al. have reported on the clinical viability of the MPS 9000, a heterochromatic flicker photometry (HFP) device used to estimate macular pigment optical density (MPOD).[1] Coefficient of repeatability (CoR) values were used to determine the test-retest repeatability and reproducibility of the MPS 9000. While the observed CoR of 0.33 is indeed high, and, superficially at least, raises concern regarding the clin...

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  • Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents
    Ali A Zaidi

    We read with great interest the article by Good et al. titled "Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents." Authors of other case series have reported sustained intraocular pressure (IOP) elevation following bevacizumab and ranibizumab injections. Good et al. conducted a retrospective chart review of 215 eyes receiving anti-VEGF injections to answer the following ques...

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  • Case-control or cohort study?
    Ashutosh Tamhane

    To The Editor,

    In a recently published article by Chandra et al. the authors have stated that they conducted a "case-controlled" study to examine the anticoagulant effectiveness of warfarin in vitreoretinal surgery.(1) However, this study was conducted on a cohort of patients receiving pars plana vitrectomy (PPV); 60 patients who received warfarin (exposure) on the day of PPV were selected. These 'exposed' pati...

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  • Need to further investigate the efficacy of valproic acid therapy in retinal degenerative disorders
    Sujoy Khan

    Dear Editor,

    We have a few concerns on the report by Clemson CM et al on the efficacy of valproic acid (VPA) in 7 patients with retinitis pigmentosa (RP) [1]. Was the time period of 6 months for using VPA the maximum time that was allowed by the institutional review boards? The degree to which the retina was affected by RP was not mentioned in each case (either in the form of photographic evidence or by electro...

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  • Re:Response to Outcomes of orbital blowout fracture surgery in children and adolescents
    Stephen G J Ng

    Dear Editor, we thank West et al. for their interest in our paper. Firstly, we wish to point out that as stated in our paper's conclusion, we fully endorse early surgery in all cases of paediatric & adolescent blowout fracture. We are committed to educating referrers and colleagues in other specialities to recognize & refer these patients as soon as possible. Secondly, West et al claim that we did not adequatel...

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  • Is patching appropriate therapy?
    Philip Lempert

    Newsham's recent article on the management of amblyopia is timely but misdirected. Illusions concerning occlusion therapy are repeated with tourettic persistence despite a lack of supporting objective scientific evidence. (Gregson R. Why are we so bad at treating amblyopia. Eye 2002;16:461-2)

    Reports of effective treatment are diminished by the number of subjects who decide to discontinue treatment. Of tho...

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  • Re:Lack of scientific rationale for use of valproic acid for retinitis pigmentosa
    Shalesh Kaushal

    Authors' Reply to Sandberg et al. letter entitled "Lack of scientific rationale for use of valproic acid for retinitis pigmentosa"

    Radouil Tzekov 1, Carol Bigelow2, Christine Clemson1, Jenna Checchi1, Mark Krebs3, Shalesh Kaushal1

    Author Affiliations

    1 Department of Ophthalmology University of Massachusetts Medical School Worcester, MA, USA

    2 Division of Biostatistics and Epidemiology/D...

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  • Lack of scientific rationale for use of valproic acid for retinitis pigmentosa
    Michael A. Sandberg

    Lack of Scientific Rationale for Use of Valproic Acid for Retinitis Pigmentosa

    Michael A. Sandberg, Ph.D., Bernard Rosner, Ph.D., Carol Weigel- DiFranco, Eliot L. Berson, M.D.

    Corresponding author: Michael A. Sandberg, Ph.D. Berman-Gund Laboratory, Harvard Medical School 243 Charles Street Boston, Massachusetts 02114 USA Email: Michael_sandberg@meei.harvard.edu Telephone: 617-573-3605 FAX: 617-573-3216...

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  • Registration for people with sight impairment - a valued system
    Catey Bunce

    Ryan and Margrain's letter highlights some key findings from a report they conducted on behalf of the Thomas Pocklington Trust. 1 They found that there are many people in Wales requiring visual rehabilitation who do not meet the current criteria for certification as visually impaired. They found also that there had been poor uptake in Wales of systems which were designed to support those who need aid who do not meet such...

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  • Author's response
    Hannah E Bartlett

    As a research group with no commercial interest in any macular pigment optical density (MPOD) measurement devices, or nutritional supplements, we feel that we were well-placed to carry out this independent clinical assessment of the reliability of MPS 9000. Our study was prompted by the fact that we could find no reported coefficient of repeatability value within the literature, and none was provided by the manufacturer...

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