106 e-Letters

published between 2013 and 2016

    Gonzaga Garay-Aramburu

    In the recent article published in British Journal of Ophthalmology, Agrawal et al1

    reported two cases of desegmentation of Ozurdex implant in vitreous cavity. In this report, the authors comment that Allergan confirmed that fractured implants in the applicator have not been found to date during the quality control process. We recently reported2

    also two cases of implant fragmentation in response t...

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  • Is the term dry eye a misnomer?

    As an ophthalmologist for many years, I continue to find the diagnosis of dry eye difficult unless it is severe. I have spoken to colleagues who have the same experience. As detailed in this paper there are many things going on in the pathophysiology of which dryness may be one. Can I suggest it might be helpful to our understanding and approach to sore eyes, to be less dogmatic about attributing dryness as the reason f...

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  • Significant design flaws bias the results in favour of aflibercept
    Andrew Zambanini

    Dr Cho and colleagues present data on a very small cohort of patients with wet AMD that have switched treatment from either bevacizumab or ranibizumab to aflibercept. Of note, this subgroup comprised approximately 8% of the total number of patients switched to aflibercept.

    Any retrospective review is likely to be heavily biased by the anticipated 'treatment benefit' of a new therapy particularly if, as in this ca...

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  • The long-term psychosocial impact of correction surgery for adults with strabismus
    Gerald McGwin

    We read with interest Jackson and Morris's response to our letter.

    The author's indicated that it was not possible to conduct a repeated measures ANOVA using SPSS. However, SPSS provides several ways to analyze repeated measures ANOVA through the general linear model command. There are several excellent texts that illustrate how to conduct an ANOVA using a repeated measures design in the SPSS environment....

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  • Re:Non-inferiority or superiority?
    Etsuko Takamura

    We would like to thank Dr. Geitzenauer for his comments and concerns regarding our study.

    As he has pointed out, in a non-inferiority study there is potential for bias which may narrow down the difference in efficacy. Therefore, conducting a superiority study simultaneously would be difficult, unless sufficient quality is ensured during study planning, conduct as well as data analysis.

    However, our st...

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  • Non-inferiority or superiority?
    Wolfgang Geitzenauer

    Dear editors,

    Takamura et al. report in a recent edition of the BJO about a "multi- center, randomised, double-masked, parallel study" which leads to both a non-inferiority and a superiority claim of the ophthalmic solution being tested (diquafosol ophthalmic solution).(Reference 1) From a methodological standpoint, the conclusions reached by the authors are not in agreement with current accepted standards in th...

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