eLetters

134 e-Letters

published between 2016 and 2019

  • Cigarette smoke extract-mediated oxidative stress and fibrotic-related genes expression may contribute to poor response to steroids therapy in Graves' ophthalmopathy
    Yu-Fan Chang

    We read with great interest the article entitled "Smoking was associated with poor response to intravenous steroids therapy in Graves' ophthalmopathy" by Xing et al [1]. Cigarette smoking is known to be the most important risk factor for the development or deterioration of GO, and it is associated with poor response to treatment for GO. However, the exact mechanisms which prove deleterious effect of cigarette smoking on GO rem...

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  • Increased expression of connective tissue growth factor play a role in the pathogenesis of thyroid eye disease
    Yun-Chun Peng

    We read with great interest the article entitled "Pathogenesis of thyroid eye disease: review and update on molecular mechanisms" by Khong et al [1]. We would like to contribute to the article with our novel findings.

    In our previous study, we first demonstrated the up-regulation of mRNA and protein expression of fibrosis-related genes including fibronectin, apolipoprotein J and connective tissue growth factor...

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  • Optic disc edema in astronauts following long-duration space flight
    Thomas H. Mader

    Optic disc edema in astronauts following long-duration space flight

    We commend Morgan and colleagues for their discussion of optic disc changes during and after long-duration space flight (LDSF). 1 They note that astronauts after LDSF have developed clinical features (disc edema, globe flattening) similar to those of idiopathic intracranial hypertension (IIH) that may persist for many months post flight and sugg...

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  • RE: Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Kapetanakis, et al. 100:1 86-93 doi:10.1136/bjophthalmol-2015-307223
    Alicja R Rudnicka

    Dear Editor,

    We thank Cheng and Tham for their interest in our systematic review of global variations and time trends in primary open angle glaucoma (POAG).[1] The comments raise some important issues relating to the assimilation of evidence from observational studies, particularly in summarising estimates of chronic disease prevalence.

    Cheng and Tham have questioned our inclusive approach, which resu...

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