eLetters

644 e-Letters

  • Author Response Re: "Need to further investigate the efficacy of valproic acid therapy in retinal degenerative disorders" letter
    Radouil Tzekov

    Dear Editor,

    We appreciate the interest of Dr. Kahn and Dr. Philip [1] in our paper describing pilot results from a retrospective study in patients with retinitis pigmentosa (RP) treated with valproic acid (VPA) [2], and we would like to comment on the points raised by them.

    Length of treatment. As mentioned in our recent reply to another letter regarding the same article [3], the length of treatment...

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  • Effectiveness of ranibizumab for neovascular age-related macular degeneration using clinician-determined retreatment strategy.
    Gerassimos Lascaratos

    We read with great interest the article by Kumar et al. We have audited our 1-year results using a slightly different clinical model: a nurse-led optical coherence tomography (OCT)-guided macula service.

    Following wet AMD diagnosis in the consultant-led macula clinic, three consecutive monthly ranibizumab injections are administered. Thereafter, patients are reviewed 4-6 weekly in the nurse-led clinic for 2 visi...

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  • Tissue plasminogen activator (tPA) and retinal vein occlusion
    Stefan Mennel

    Dear editor:

    Yamamoto and coworkers present in their paper the effect of simultaneous intravitreal injection of a mixture of 4mg triamcinolone acetonide (TA) and 25?g tissue plasminogen activator (tPA) to treat macular edema due to central retinal vein occlusion (CRVO) ?1?. The authors included 20 eyes. Best corrected visual acuity (BCVA) improved three lines or more in 65%, 55%, 55% and 53% of eyes and the mea...

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  • The Statistical Interpretation of the Coefficient of Repeatability
    James Loughman

    Bartlett et al. have reported on the clinical viability of the MPS 9000, a heterochromatic flicker photometry (HFP) device used to estimate macular pigment optical density (MPOD).[1] Coefficient of repeatability (CoR) values were used to determine the test-retest repeatability and reproducibility of the MPS 9000. While the observed CoR of 0.33 is indeed high, and, superficially at least, raises concern regarding the clin...

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  • Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents
    Ali A Zaidi

    We read with great interest the article by Good et al. titled "Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents." Authors of other case series have reported sustained intraocular pressure (IOP) elevation following bevacizumab and ranibizumab injections. Good et al. conducted a retrospective chart review of 215 eyes receiving anti-VEGF injections to answer the following ques...

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  • Case-control or cohort study?
    Ashutosh Tamhane

    To The Editor,

    In a recently published article by Chandra et al. the authors have stated that they conducted a "case-controlled" study to examine the anticoagulant effectiveness of warfarin in vitreoretinal surgery.(1) However, this study was conducted on a cohort of patients receiving pars plana vitrectomy (PPV); 60 patients who received warfarin (exposure) on the day of PPV were selected. These 'exposed' pati...

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  • Need to further investigate the efficacy of valproic acid therapy in retinal degenerative disorders
    Sujoy Khan

    Dear Editor,

    We have a few concerns on the report by Clemson CM et al on the efficacy of valproic acid (VPA) in 7 patients with retinitis pigmentosa (RP) [1]. Was the time period of 6 months for using VPA the maximum time that was allowed by the institutional review boards? The degree to which the retina was affected by RP was not mentioned in each case (either in the form of photographic evidence or by electro...

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  • Re:Response to Outcomes of orbital blowout fracture surgery in children and adolescents
    Stephen G J Ng

    Dear Editor, we thank West et al. for their interest in our paper. Firstly, we wish to point out that as stated in our paper's conclusion, we fully endorse early surgery in all cases of paediatric & adolescent blowout fracture. We are committed to educating referrers and colleagues in other specialities to recognize & refer these patients as soon as possible. Secondly, West et al claim that we did not adequatel...

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  • Is patching appropriate therapy?
    Philip Lempert

    Newsham's recent article on the management of amblyopia is timely but misdirected. Illusions concerning occlusion therapy are repeated with tourettic persistence despite a lack of supporting objective scientific evidence. (Gregson R. Why are we so bad at treating amblyopia. Eye 2002;16:461-2)

    Reports of effective treatment are diminished by the number of subjects who decide to discontinue treatment. Of tho...

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  • Re:Lack of scientific rationale for use of valproic acid for retinitis pigmentosa
    Shalesh Kaushal

    Authors' Reply to Sandberg et al. letter entitled "Lack of scientific rationale for use of valproic acid for retinitis pigmentosa"

    Radouil Tzekov 1, Carol Bigelow2, Christine Clemson1, Jenna Checchi1, Mark Krebs3, Shalesh Kaushal1

    Author Affiliations

    1 Department of Ophthalmology University of Massachusetts Medical School Worcester, MA, USA

    2 Division of Biostatistics and Epidemiology/D...

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