eLetters

644 e-Letters

  • Lack of scientific rationale for use of valproic acid for retinitis pigmentosa
    Michael A. Sandberg

    Lack of Scientific Rationale for Use of Valproic Acid for Retinitis Pigmentosa

    Michael A. Sandberg, Ph.D., Bernard Rosner, Ph.D., Carol Weigel- DiFranco, Eliot L. Berson, M.D.

    Corresponding author: Michael A. Sandberg, Ph.D. Berman-Gund Laboratory, Harvard Medical School 243 Charles Street Boston, Massachusetts 02114 USA Email: Michael_sandberg@meei.harvard.edu Telephone: 617-573-3605 FAX: 617-573-3216...

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  • Registration for people with sight impairment - a valued system
    Catey Bunce

    Ryan and Margrain's letter highlights some key findings from a report they conducted on behalf of the Thomas Pocklington Trust. 1 They found that there are many people in Wales requiring visual rehabilitation who do not meet the current criteria for certification as visually impaired. They found also that there had been poor uptake in Wales of systems which were designed to support those who need aid who do not meet such...

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  • Author's response
    Hannah E Bartlett

    As a research group with no commercial interest in any macular pigment optical density (MPOD) measurement devices, or nutritional supplements, we feel that we were well-placed to carry out this independent clinical assessment of the reliability of MPS 9000. Our study was prompted by the fact that we could find no reported coefficient of repeatability value within the literature, and none was provided by the manufacturer...

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  • M. tuberculosis in donor corneal tissue
    Soumyava Basu
    Dear editor, I read with interest Catederal et alâ₉„¢s study on the use of polymerase chain reaction (PCR) for detection of Mycobacterium tuberculosis in donor corneal tissues.1 The authors report the presence of M. tuberculosis DNA in donor corneas of patients with no documented history of tuberculosis. However there are several methodological erro...
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  • Re:Conclusions of Clemson et al. concerning Valproic Acid are premature
    Shalesh Kaushal

    Dear Editor,

    We appreciate the interest of Van Schooneveld et al.1 in our recent BJO article.2 Our small, retrospective chart review of RP patients treated off-label with valproic acid is only the first step in the process of understanding the potential utility of the drug for patients with this sight-threatening condition, for which there are no current therapeutic options.

    The size and the scope of...

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  • Conclusions of Clemson et al. concerning Valproic Acid are premature
    Mary J. van Schooneveld

    Dear Sir, With great interest we read the article of Clemson et al. about a new treatment for retinitis pigmentosa (RP). However, the authors' claim that their data suggest that valproic acid (VPA) may be an effective treatment for RP is unfounded and also regrettably misleading for the many desperate RP-patients. In fact, we are surprised that the editors of the BJO have published this study in its present form. Firstly,...

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  • Response to distal enlargement of the optic nerve sheath in the hyperacute stage of intracerebral haemorrhage
    Riccardo Moretti

    Dear Editor, we have read with great interest the article of Skoloudik and coworkers on the use of optic nerve ultrasonography in patients with intracranial hemorrhage (ICH). The primary goal of this study was to investigate the variations of the optic nerve sheath diameter (ONSD) early after the onset of ICH. The authors should be commended for pointing out our interest towards a new parameter (the relative difference be...

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  • educational/motivational intervention and amblyopia treatment:
    professor viroj wiwanitkit

    Editor, I read the recent publication by Awan et al. with a great interest [1]. Awan et al. concluded that "As compliance has been identified as a major problem methods to improve amblyopia treatment are needed, possibly by using educational/motivational intervention [1]." Recently, Lee et al. proposed that "Poor compliance with occlusion therapy was less likely to achieve successful outcome [2]." Indeed, "how complianc...

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  • Response to Outcomes of orbital blowout fracture surgery in children and adolescents
    Stephanie K West

    Dear Editor, We thank Authors S.C. Carroll et al for their interesting paper on the Outcomes of orbital blowout fracture surgery in children and adolescents.1 We agree that autonomic symptoms of nausea and vomiting should alert the clinician to the high likelihood of significant orbital trauma. This study shows that the overall outcomes for all patients under the age of 20 were good despite delays. However, this is a hete...

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  • CUSUM for monitoring competency: Computer software is useful for bootstrapping and real time CUSUM plotting.
    Jacob M. Puliyel

    We congratulate Salowi and colleagues on their study of the use of CUSUM to monitor competency in cataract extraction (1). However there are two modifications that could make their system more responsive and reliable.

    Firstly the authors use a CUSUM chart that fluctuates on only one side of the zero line. Traditionally CUSUM charts fluctuate on both sides of the zero line (2,3). The consultant in their Figure 1...

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