629 e-Letters

  • Re: e Letter for bjophthalmol-2017-310312; Comments on article “Impact of Surgical Timing of Postoperative Ocular Motility in Orbital Blowout Fractures”

    Dr. Jost Jonas

    British Journal of Ophthalmology


    Dear Dr. Jonas:


    With great interest, we read the e letter (E-Letter 1) submitted by Ankita Anil Patil, Srikanth Ramsubramanian, and Bipasha Mukherjee, entitled “Comments on article ‘Impact of surgical timing on postoperative ocular motility in orbital blowout fractures’” illustrating their analysis and opinions on our article that was recently published in the British Journal of Ophthalmology. Please know that we greatly appreciate the authors’ cogent and helpful comments.


    It should be noted that in our opinion, in order to normalize ocular motility, the most important aspect is to restore the orbital tissues for the appropriate location. It is quite well known that the transcaruncular approach is suitable for small fractures of the medial wall. Since the transcaruncular approach provides surgeons with only a narrow view, it is difficult to restore the orbital tissues for the appropriate location for a large depressed fracture. On the other hand, the Lynch incision provides a substantial advantage for the repair of an orbital fracture, as it allows for a wide view during surgery and makes it easy to restore the orbital tissues for the orbit and insert the reconstruction implant. In additi...

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  • Building a reliable evidence base in eyes and vision

    Dear Editors,

    We are writing to express concerns about an article published recently in BJO. (1) While Joksimovic and colleagues claim to have conducted a systematic review, they did not. Rather, they describe a cross-sectional study of randomized trials in ophthalmology with two comparison (or “exposure”) groups: trials published in ophthalmology journals, and trials published in general medical journals. In contrast, a systematic review (also a cross sectional study) has been defined as "… a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies." (2)

    To minimize mislabeling of systematic reviews, among other purposes, Cochrane Eyes and Vision (CEV) is partnering with individual ophthalmology and optometry journals to appoint a knowledgeable associate editor responsible for editorial functions related to systematic reviews at each journal (http://eyes.cochrane.org/associate-editors-eyes-and-vision-journals). Our research has indicated that many published eye and vision articles billed as “systematic reviews” do not adhere to accepted criteria, and are not reliable. (3)

    In addition to adding associate editors for systematic reviews to their team, journal editors can insist that authors adhere to reporting standards, f...

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  • Reply to Aptel et al.: Management of postoperative inflammation after cataract and complex ocular surgeries: a systematic review and Delphi survey

    Aptel et al. [1] presented the prevention and management of postoperative ocular inflammation after cataract surgery based on randomised controlled trials, while after trabeculectomy, vitrectomy and combined phacovitrectomy in a two-round Delphi survey.

    The Delphi survey is a technique applied mainly to develop healthcare quality indicators. [2] In this study not only was it applied to evaluate practice patterns among ophthalmologists, but to obtain information on inflammatory potential of a surgical procedure that can be assessed by objective methods.

    It should be underlined that even within the formerly mentioned indications there is little recommendation among researchers to use the Delphi method. [2] The use and reporting of the method needs to be improved, while a panel composition of experts in one field significantly influences ratings. [2,3] Several issues regarding the selection of the panel members is critical if the group consensus technique is to work properly. Two hundred and twenty surgeons from Europe (35%) and the USA (59%) were invited to participate in this Delphi survey. The response rate among the invited experts should be thoroughly explained, as finally 82% of the participating experts were from Europe and the balance was from the USA. This discrepancy might have a high risk of bias and should be thoroughly discussed. Of record, in the United States retinal surgeons do not routinely perform cataract surgery, thus including them in the e...

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  • Comments on article "Impact of surgical timing on postoperative ocular motility in orbital blowout fractures

    We have read the article”Impact of surgical timing of postoperative ocular motility in orbital blowout fractures” by Yukito Yamanaka, Akihide Watanabe, Chie Sotozono, Shigeru Kinoshita published in BJO on July 25 2017.The article discusses a new technique of Hess Area Ratio (HAR) and CT-scan findings for determining the appropriate time for surgery and predict the outcomes following orbital fracture repair.
    We want to congratulate the authors for this successful review article. We would like to comment on some points in the methodology and results of this article and make some contributions.The incisions described in the article have some shortcomings and are not currently the favoured approach. The Lynch incision described in the article has been the traditional approach for medial wall fractures but can result in severe scarring or webbing of the medial canthal skin ; therefore the transcaruncular approach is favoured.1 The subciliary incision too can cause ectropion and a transconjunctival approach is preferred.2 The number of patients mentioned in the results section who had poor improvement of HAR% differs being recorded as 22 earlier and then later in the article as 24.The diagnosis of tissue incarceration causing ocular motility disturbances after surgery is more related to various ocular motility tests rather than CT-SCAN findings alone.3 The authors have diagnosed muscle and tissue incarceration based solely on CT-SCAN findings and have not commented on t...

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  • Comment on “The role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma”

    Kenzo J. Koike, MD1; Lauren S. Blieden, MD1,2; Yvonne I. Chu, MD1; Silvia Orengo-Nania, MD1,2; Kristin S. Biggerstaff, MD2; Bac T. Nguyen, MD1; Peter T. Chang, MD1,2; Benjamin J. Frankfort, MD, PhD1

    Assessing the visual standards to safely operate a motor vehicle is a challenging topic and discussion that we regularly encounter in our glaucoma population. Multi-centered and population-based studies previously have shown that patients with glaucoma are at particularly increased driving risk, due to their visual deficits.1,2 As such, we greatly appreciate the contributions from Kunimatsu-Sanuki and colleagues, who evaluated patients with advanced glaucoma, and how they performed with a driving simulator. As part of their analysis, the authors focused on specific visual sub-fields, and how those may correlate with the incidence of motor vehicle collisions (MVCs). Their conclusions noted that inferior visual field deficits, age, and visual acuity, were significant factors that contributed to the rate of MVCs. However, we noticed that visual acuity of the better eye (recorded as logMAR) was a significantly higher risk factor (odds ratio of 28.59 and 75.71 for analyses 1 and 2, respectively, as shown in Table 3) for collisions during simulated driving. With such a dramatically higher risk of simulated collision based on visual acuity, it is likely that this parameter alone is the most significant factor to influence the risk of MVCs. As there is some discrepancy in the li...

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  • Optic nerve head swelling on ultrasound and optical coherence tomography in children

    Dear Editor,
    we read with great interest the article by Dahlmann-Noor et al. concerning the possibility to detect optic nerve (ON) head swelling on ultrasound and OCT. 1
    They reported 61 children , investigated for ‘suspicious discs’ that underwent both US and OCT. Among these only 3 children had intracranial hypertension (IHT) but all of them were diagnosed as having drusen on US; even the three children with IHT had ‘small linear’ drusen.
    We would like to comment on small linear drusen that seem to have been undetected by OCT. This is very unlikely. Much care must be taken to diagnose linear drusen with ultrasound because this image could be an artifact due to the strong echoes coming from a surface where the sound beam is perpendicular .
    Measuring optic nerve sheath diameter (ONSD) with B-scan has recently become popular, but there is not a global agreement on how to perform such a measurement as some authors suggest performing axial measurements, some others coronal axis measurements.3-5 Furthermore to establish a cutoff between normal and increased ONSD can be very challenging due to the so-called blooming effect. This B-scan related effect, that should not be confused with the Doppler related one, is due to the lack of sensitivity standard setting: the ON image obtained with a low sensitivity setting will result in larger ON dimensions compared to the ones provided by the same image, increasing the sensitivity setting.
    The authors...

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  • Comment: “The patient is speaking”: discovering the patient voice in ophthalmology

    We have read with interest the article by Dean et al(1). We completely agree with the premise that the ‘patient voice’ is not being fully utilised in all facets of ophthalmic care, ranging from research to clinical practice. Evidence suggests that rather than being a tokenistic addition, listening to the ‘patient voice’ can provide tangible improvements in cost efficiency and healthcare outcomes(2).

    A successful project spearheaded by the European Respiratory Society (ERS) called EMBARC(3) (European Multicentre Bronchiectasis Audit and Research Collaboration) sought to be a patient focused project, despite scarce existing infrastructure for patient involvement(3). In the research sphere of the project, patients were involved in clinical trials and studies. They played key roles in study design, wrote letters to secure financial backing for bronchiectasis-related projects, and were active members of advisory boards and ethical committees. Patients were a valuable asset on guideline panels, providing an alternative insight on the merits and negatives of various interventions, as well as their general acceptability. This initiative is a model example of how patients can influence the path research takes, and provides a tested framework for future ophthalmic research to be highly patient-relevant.

    Undoubtedly, there will be barriers to effective patient involvement in medical research and these will require flexible and innovative approaches to be overcome. These...

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  • Classification Of Diabetic Macular Odema Using Ultra- Wide field angiography and implications for response to anti-VEGF therapy

    Dear Sir,
    We read the article "Classification of diabetic macular odema using ultra-widefield angiography and implications for response to anti-VEGF therapy" by Xue K, et al1 with great interest. The authors aimed to classify Diabetic macular odema [DMO] using ultra-widefield flourescein angiography [UWFA] and evaluate response to anti-vascular endothelial growth factor [anti-VEGF]. They concluded that UWFA facilitates detection of peripheral ishemia. DMO group with significant peripheral ishemia responded well to anti-VEGF therapy than other groups. We congratulate the author for their lightening study about subject and would like to make some contributions about study.
    The study did not mention the severity of diabetes of the patients enrolled in the study nor systemic comorbid conditions like glycemic control, systolic hypertension, protinuria1, which would alter the incidence of macular odema.2, 3
    The study selected patients with DMO who have been given subthreshold micropulse diode laser. As it was not mentioned in the study, we wonder if the study desires to see the response of anti-VEGF in non-resolving macular odema patients alone. Also, it was to our surprise why patients with Panretinal photocoagulation were not excluded from the study while classifying the patients into 3 groups .
    The classification of DMO into three groups was not clearly satisfying because there would be always a component of ishemia overlapping between t...

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  • Response to Thevi T comments

    Dear Sir
    Thanks for this notification
    1. Preoperative and postoperative characteristics for the CF group are shown in Table 2 (line 13)
    Answer: This was a typing error hoping if it will be corrected to: preoperative and postoperative characteristics for the AMG group are shown in Table 2
    2. The study does not mention about the location postoperatively. How will the site of the ulcer change from central to paracentral and vice versa?
    Answer: Eighteen from twenty patients in each group showed healing of the ulcer, and two cases in each group were sent for keratoplasty (from 4 to 8 days after intervention). So, there is no need to mention size of the ulcer. Regarding site of the ulcer; some paracentral ulcer are creeping and/or enlarging in size to involve the central part.
    Regarding site of the ulcer; some paracentral ulcer are creeping and/or enlarging in size to involve the central part.
    So the description of the ulcer will be changed from peripheral to central.
    There was no need to mention this as the ulcers healed.
    3. There is no mention about the complications studied. Descemetocele and perforations occurred preoperatively.
    Answer: Three cases with perforation and one case with descemetocele were referred to immediate keratoplasty, and other ulcers healed, so there were no complications to be mentioned. Regarding other complications in secondary outcome measures, there were no complications and this was mentio...

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  • Bilateral Descemet membrane detachment and Terrien’s marginal degeneration

    We read with interest the study by Odayappan et al regarding outcomes of air descemetopexy for Descemet membrane detachment (DMD). [1] It is interesting to note the lack of corneal pathology associated with DMD in their case series, and the discussion regarding the contribution of incision sites. We would like to raise the issue of peripheral corneal pathology as a contributing factor in DMD. Recently we had a complex case involving a 91-year-old with extensive Terrien’s marginal degeneration and corneal scarring, who underwent right cataract surgery. This was complicated by DMD and he had successful air descemetopexy within the first month. He then proceeded to have left cataract surgery, with a residual air bubble left in the anterior chamber, yet he still developed DMD. We scheduled surgery but he was unable to attend due to illness and hospital admission. When he was reviewed at 3 months post operatively, the DMD had reattached, with normalised pachymetry and visual acuity of 6/12 bilaterally.

    While we agree that air descemetopexy is an efficient treatment modality for DMD, our case highlights that other co-morbidities can influence management. As the anatomical and visual outcomes were similar in both eyes, our case raises the issue of lack of clear guidance in the literature regarding when to intervene in DMD and when to observe.

    Terrien’s marginal degeneration is a slowly progressive thinning of the peripheral cornea, with formation of a scarred gutte...

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