TY - JOUR T1 - Atenolol eye drops in glaucoma: a double-masked, controlled study. JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 349 LP - 353 DO - 10.1136/bjo.61.5.349 VL - 61 IS - 5 AU - C. I. Phillips AU - S. M. Gore AU - M. J. Macdonald AU - P. M. Cullen Y1 - 1977/05/01 UR - http://bjo.bmj.com/content/61/5/349.abstract N2 - Guttae atenolol 4% (Tenormin), a pure beta1-blocking (i.e., cardioselective) drug, produced a median overall fall of 5-6 mmHg (range 3-2 to 13-2 mmHg) in the first tonometrised eyes of 7 patients with open-angle glaucoma or ocular hypertension and 1 with closed-angle glaucoma (off any treatment for the whole of the day preceding each test day) after allowance for an 'effect' of guttae saline 0-9%, in a double-masked, cross-over trial. By a Wilcoxon matched pairs rank test this was significant at the P less than 0-05 level. The median overall fall of 3-5 mmHg (range 0-8 to 10-8 mmHg) in the second-tonometrised eyes of 7 patients (1 of the 8 contributed only 1 eye) was also significant (P less than 0-05). In 2 patients who had been treated with guttae atenolol 4% daily 3 X for 1 and 2 months there is evidence that, on replacing the atenolol 4% with saline 0-9%, a rise of pressure of around 3 mmHg occurred 2 and 3 and 5 days later, i.e., the drug still retained its effectivity (slightly reduced) after 1 and 2 months. ER -